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心脏手术后早期行气管切开术可改善中期和长期生存率。

Early tracheostomy after cardiac surgery improves intermediate- and long-term survival.

机构信息

Department of Cardiac Surgery, Leviev Cardiothoracic and Vascular Centre, Sheba Medical Center, affiliated to the Sackler School of Medicine, Tel Aviv University, Israel.

Department of Anaesthesiology, Sheba Medical Centre, affiliated to the Sackler School of Medicine, Tel Aviv University, Israel.

出版信息

Med Intensiva (Engl Ed). 2023 Sep;47(9):516-525. doi: 10.1016/j.medine.2023.02.003. Epub 2023 Mar 1.

Abstract

OBJECTIVE

Complicated post-cardiac surgery course, can lead to both prolonged ICU stay and ventilation, and may require a tracheostomy. This study represents the single-center experience with post-cardiac surgery tracheostomy. The aim of this study was to assess the timing of tracheostomy as a risk factor for early, intermediate, and late mortality. The study's second aim was to assess the incidence of both superficial and deep sternal wound infections.

DESIGN

Retrospective study of prospectively collected data.

SETTING

Tertiary hospital.

PATIENTS

Patients were divided into 3 groups, according to the timing of tracheostomy; early (4-10 days); intermediate (11-20 days) and late (≥21 days).

INTERVENTIONS

None.

MAIN VARIABLES OF INTEREST

The primary outcomes were early, intermediate, and long-term mortality. The secondary outcome was the incidence of sternal wound infection.

RESULTS

During the 17-year study period, 12,782 patients underwent cardiac surgery, of whom 407 (3.18%) required postoperative tracheostomy. 147 (36.1%) had early, 195 (47.9%) intermediate, and 65 (16%) had a late tracheostomy. Early, 30-day, and in-hospital mortality was similar for all groups. However, patients, who underwent early- and intermediate tracheostomy, demonstrated statistically significant lower mortality after 1- and 5-year (42.8%; 57.4%; 64.6%; and 55.8%; 68.7%; 75.4%, respectively; P < .001). Cox model demonstrated age [1.025 (1.014-1.036)] and timing of tracheostomy [0.315 (0.159-0.757)] had significant impacts on mortality.

CONCLUSIONS

This study demonstrates a relationship between the timing of tracheostomy after cardiac surgery and mortality: early tracheostomy (within 4-10 days of mechanical ventilation) is associated with better intermediate- and long-term survival.

摘要

目的

心脏手术后的复杂病程可能导致 ICU 住院时间延长和通气时间延长,并可能需要进行气管切开术。本研究代表了心脏手术后气管切开术的单中心经验。本研究的目的是评估气管切开术的时机作为早期、中期和晚期死亡率的危险因素。该研究的第二个目的是评估表浅和深部胸骨伤口感染的发生率。

设计

前瞻性收集数据的回顾性研究。

设置

三级医院。

患者

根据气管切开术的时机,患者分为 3 组:早期(4-10 天);中期(11-20 天)和晚期(≥21 天)。

干预措施

无。

主要观察变量

主要结局是早期、中期和长期死亡率。次要结局是胸骨伤口感染的发生率。

结果

在 17 年的研究期间,12782 例患者接受了心脏手术,其中 407 例(3.18%)需要术后气管切开术。147 例(36.1%)为早期,195 例(47.9%)为中期,65 例(16%)为晚期。所有组的早期、30 天和住院死亡率相似。然而,接受早期和中期气管切开术的患者在 1 年和 5 年时的死亡率有统计学意义较低(分别为 42.8%、57.4%、64.6%和 55.8%、68.7%、75.4%;P<0.001)。Cox 模型显示年龄[1.025(1.014-1.036)]和气管切开术时机[0.315(0.159-0.757)]对死亡率有显著影响。

结论

本研究表明心脏手术后气管切开术时机与死亡率之间存在关系:早期气管切开术(机械通气后 4-10 天内)与中期和长期生存相关。

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