Ahmed Jasim, Thomas Linu, Mulla Mehrajfatema Z, Al-Attar Hasan, Maniruzzaman M
Environment & Life Sciences Research Center, Kuwait Institute for Scientific Research, P.O. Box 24885, Safat 13109, Kuwait.
Environment & Life Sciences Research Center, Kuwait Institute for Scientific Research, P.O. Box 24885, Safat 13109, Kuwait.
Food Res Int. 2023 Mar;165:112497. doi: 10.1016/j.foodres.2023.112497. Epub 2023 Jan 24.
In this work, a twin-screw dry granulation (TSDG) was adopted to produce vitamin D3 (VD3) and iron blended dry granules using corn starch as an excipient. Response surface methodology was applied to determine the effect of the formulation compositions (VD3 and iron) on granule properties [tapped bulk density, oil holding capacity, and volumetric mean particle size (D50)]. Results indicated that the model fitted well, and responses, in particular flow properties, were significantly affected by the composition. The D50 was only influenced by the addition of VD3. The flow properties were characterized by the Carr index and Hausner ratio, which indicated very poor flow of the granules. Scanning electron microscopy with energy dispersive spectroscopy confirm the presence and distribution of Fe and VD3 in the granules. Overall, TSDG was proven to be a simple alternative method for the preparation of dry granules of VD3 and iron in a blend.
在本研究中，采用双螺杆干法制粒（TSDG）以玉米淀粉为辅料制备维生素D3（VD3）与铁混合的干颗粒。应用响应面法来确定配方组成（VD3和铁）对颗粒性质[振实堆密度、持油能力和体积平均粒径（D50）]的影响。结果表明模型拟合良好，且响应，特别是流动性质，受组成的显著影响。D50仅受VD3添加量的影响。流动性质通过卡尔指数和豪斯纳比来表征，结果表明颗粒的流动性非常差。带有能谱的扫描电子显微镜证实了颗粒中Fe和VD3的存在及分布。总体而言，TSDG被证明是一种制备VD3与铁混合干颗粒的简单替代方法。
