Department of Pharmacological Sciences, Department of Artificial Intelligence and Human Health, Mount Sinai Center for Bioinformatics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1603, New York, NY 10029, USA.
Database (Oxford). 2023 Mar 4;2023. doi: 10.1093/database/baad009.
Long non-coding ribonucleic acids (lncRNAs) account for the largest group of non-coding RNAs. However, knowledge about their function and regulation is limited. lncHUB2 is a web server database that provides known and inferred knowledge about the function of 18 705 human and 11 274 mouse lncRNAs. lncHUB2 produces reports that contain the secondary structure fold of the lncRNA, related publications, the most correlated coding genes, the most correlated lncRNAs, a network that visualizes the most correlated genes, predicted mouse phenotypes, predicted membership in biological processes and pathways, predicted upstream transcription factor regulators, and predicted disease associations. In addition, the reports include subcellular localization information; expression across tissues, cell types, and cell lines, and predicted small molecules and CRISPR knockout (CRISPR-KO) genes prioritized based on their likelihood to up- or downregulate the expression of the lncRNA. Overall, lncHUB2 is a database with rich information about human and mouse lncRNAs and as such it can facilitate hypothesis generation for many future studies. The lncHUB2 database is available at https://maayanlab.cloud/lncHUB2. Database URL: https://maayanlab.cloud/lncHUB2.
长链非编码核糖核酸（lncRNAs）构成了最大的非编码 RNA 组。然而，人们对其功能和调控的了解还很有限。lncHUB2 是一个网络服务器数据库，提供了已知和推断的 18705 个人类和 11274 个小鼠 lncRNA 的功能知识。lncHUB2 生成的报告包含 lncRNA 的二级结构折叠、相关出版物、最相关的编码基因、最相关的 lncRNA、可视化最相关基因的网络、预测的小鼠表型、预测的生物过程和途径成员、预测的上游转录因子调节剂，以及预测的疾病关联。此外，报告还包括亚细胞定位信息；在组织、细胞类型和细胞系中的表达情况，以及根据其上调或下调 lncRNA 表达的可能性进行优先级排序的预测小分子和 CRISPR 敲除（CRISPR-KO）基因。总体而言，lncHUB2 是一个包含丰富人类和小鼠 lncRNA 信息的数据库，因此它可以为许多未来的研究提供假设生成的依据。lncHUB2 数据库可在 https://maayanlab.cloud/lncHUB2 上获取。数据库网址：https://maayanlab.cloud/lncHUB2。
