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阔叶层孔菌与运动训练作为辅助医学减轻了结直肠癌小鼠5-氟尿嘧啶的强效副作用：生物信息学方法、新型监测病理指标、筛选特征及创新管理策略。

Sparassis latifolia and exercise training as complementary medicine mitigated the 5-fluorouracil potent side effects in mice with colorectal cancer: bioinformatics approaches, novel monitoring pathological metrics, screening signatures, and innovative management tactic.

作者信息

Abedpoor Navid, Taghian Farzaneh, Jalali Dehkordi Khosro, Safavi Kamran

机构信息

Department of Sports Physiology, Faculty of Sports Sciences, School of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.

Department of Plant Biotechnology, Medicinal Plants Research Centre, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.

出版信息

Cancer Cell Int. 2024 Apr 18;24(1):141. doi: 10.1186/s12935-024-03328-y.

DOI:10.1186/s12935-024-03328-y
PMID:38637796
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11027426/
Abstract

BACKGROUND

Prompt identification and assessment of the disease are essential for reducing the death rate associated with colorectal cancer (COL). Identifying specific causal or sensitive components, such as coding RNA (cRNA) and non-coding RNAs (ncRNAs), may greatly aid in the early detection of colorectal cancer.

METHODS

For this purpose, we gave natural chemicals obtained from Sparassis latifolia (SLPs) either alone or in conjunction with chemotherapy (5-Fluorouracil to a mouse colorectal tumor model induced by AOM-DSS. The transcription profile of non-coding RNAs (ncRNAs) and their target hub genes was evaluated using qPCR Real-Time, and ELISA techniques.

RESULTS

MSX2, MMP7, ITIH4, and COL1A2 were identified as factors in inflammation and oxidative stress, leading to the development of COL. The hub genes listed, upstream regulatory factors such as lncRNA PVT1, NEAT1, KCNQ1OT1, SNHG16, and miR-132-3p have been discovered as biomarkers for prognosis and diagnosis of COL. The SLPs and exercise, effectively decreased the size and quantity of tumors.

CONCLUSIONS

This effect may be attributed to the modulation of gene expression levels, including MSX2, MMP7, ITIH4, COL1A2, PVT1, NEAT1, KCNQ1OT1, SNHG16, and miR-132-3p. Ultimately, SLPs and exercise have the capacity to be regarded as complementing and enhancing chemotherapy treatments, owing to their efficacious components.

摘要

背景

及时识别和评估该疾病对于降低结直肠癌（COL）相关死亡率至关重要。识别特定的因果或敏感成分，如编码RNA（cRNA）和非编码RNA（ncRNA），可能极大地有助于结直肠癌的早期检测。

方法

为此，我们将从宽鳞多孔菌中获得的天然化学物质单独或与化疗药物（5-氟尿嘧啶）联合给予由AOM-DSS诱导的小鼠结直肠癌模型。使用实时定量PCR和ELISA技术评估非编码RNA（ncRNA）及其靶标枢纽基因的转录谱。

结果

MSX2、MMP7、ITIH4和COL1A2被确定为导致结直肠癌发生的炎症和氧化应激因素。已发现所列的枢纽基因、上游调控因子如lncRNA PVT1、NEAT1、KCNQ1OT1、SNHG16和miR-132-3p作为结直肠癌预后和诊断的生物标志物。宽鳞多孔菌天然化学物质（SLPs）和运动有效地减小了肿瘤的大小和数量。

结论

这种作用可能归因于基因表达水平的调节，包括MSX2、MMP7、ITIH4、COL1A2、PVT1、NEAT1、KCNQ1OT1、SNHG16和miR-132-3p。最终，由于其有效成分，宽鳞多孔菌天然化学物质和运动有能力被视为补充和增强化疗治疗。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a9c/11027426/c999b6bc4f36/12935_2024_3328_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a9c/11027426/ad0ca755b0c3/12935_2024_3328_Fig10_HTML.jpg
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