School of Chemistry and Chemical Engineering, Nanchang University, Nanchang, Jiangxi 330031, P. R. China.
College of Chemistry and Molecular Sciences, Institute for Advanced Studies (IAS), Wuhan University, Wuhan, Hubei 430072, P. R. China.
Org Lett. 2023 Mar 17;25(10):1722-1726. doi: 10.1021/acs.orglett.3c00399. Epub 2023 Mar 4.
Direct -allylation of azoles with hydrogen evolution has been achieved through the synergistic combination of organic photocatalysis and cobalt catalysis. The protocol bypasses stoichiometric oxidants and prefunctionalization of alkenes and produces hydrogen (H) as the byproduct. This transformation highlights high step- and atom-economy, high efficiency, and broad functional group tolerance for further derivatization, which opens a door for C-N bond formation that is valuable in heterocyclic chemistry.
通过有机光催化和钴催化的协同组合，实现了唑类化合物与氢的直接芳基化。该方案绕过了化学计量氧化剂和烯烃的预官能化，并生成了副产物氢气 (H)。这种转化具有高步骤经济性和原子经济性、高效率以及广泛的官能团耐受性，可进一步衍生化，为在杂环化学中具有价值的 C-N 键形成开辟了道路。
