血液癌症患者对 COVID-19 疫苗的接种率：对英格兰 1200 万患者进行的人群队列研究。

Uptake of COVID-19 vaccination in people with blood cancer: Population-level cohort study of 12 million patients in England.

机构信息

Nuffield Department of Primary Care Health Science, University of Oxford, Radcliffe Observatory Quarter, Woodstock Road, Oxford, OX2 6GG, UK.

出版信息

Eur J Cancer. 2023 Apr;183:162-170. doi: 10.1016/j.ejca.2023.02.001. Epub 2023 Feb 10.

DOI:10.1016/j.ejca.2023.02.001

PMID:36870190

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9916184/

Abstract

BACKGROUND

People with blood cancers have increased risk of severe outcomes from COVID-19 and were prioritised for vaccination.

METHODS

Individuals in the QResearch database aged 12 years and above on 1st December 2020 were included in the analysis. Kaplan-Meier analysis described time to COVID-19 vaccine uptake in people with blood cancer and other high-risk disorders. Cox regression was used to identify factors associated with vaccine uptake in people with blood cancer.

RESULTS

The analysis included 12,274,948 individuals, of whom 97,707 had a blood cancer diagnosis. 92% of people with blood cancer received at least one dose of vaccine, compared to 80% of the general population, but there was lower uptake of each subsequent vaccine dose (31% for fourth dose). Vaccine uptake decreased with social deprivation (HR 0.72, 95% CI 0.70, 0.74 for most deprived versus most affluent quintile for first vaccine). Compared with White groups, uptake of all vaccine doses was significantly lower in people of Pakistani and Black ethnicity, and more people in these groups remain unvaccinated.

CONCLUSIONS

COVID-19 vaccine uptake declines following second dose and there are ethnic and social disparities in uptake in blood cancer populations. Enhanced communication of benefits of vaccination to these groups is needed.

摘要

背景

患有血液癌症的人患 COVID-19 重症的风险增加，并被优先接种疫苗。

方法

在 2020 年 12 月 1 日，QResearch 数据库中年龄在 12 岁及以上的个体被纳入分析。Kaplan-Meier 分析描述了患有血液癌和其他高危疾病的个体接种 COVID-19 疫苗的时间。Cox 回归用于确定与血液癌患者疫苗接种相关的因素。

结果

该分析共纳入 12274948 人，其中 97707 人患有血液癌。92%的血液癌患者至少接种了一剂疫苗，而普通人群的这一比例为 80%，但随后每剂疫苗的接种率都较低（第四剂为 31%）。疫苗接种率随社会贫困程度而下降（与最富裕五分位数相比，第一剂疫苗时最贫困五分位数的 HR 为 0.72，95%CI 为 0.70-0.74）。与白人组相比，巴基斯坦裔和黑人族裔的所有疫苗剂量接种率均显著较低，且这些人群中仍有更多人未接种疫苗。