Henn Matthias, Babio Nancy, Romaguera Dora, Vázquez-Ruiz Zenaida, Konieczna Jadwiga, Vioque Jesús, Torres-Collado Laura, Razquin Cristina, Buil-Cosiales Pilar, Fitó Montserrat, Schröder Helmut, Hu Frank B, Abete Itziar, Zulet M Ángeles, Fernández-Villa Tania, Martín Vicente, Estruch Ramón, Vidal Josep, Paz-Graniel Indira, Martínez J Alfredo, Salas-Salvadó Jordi, Martínez-González Miguel A, Ruiz-Canela Miguel
University of Navarra- IdiSNA (Instituto de Investigacion Sanitaria de Navarra), Department of Preventive Medicine and Public Health, Pamplona, Spain; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
CIBER Fisiopatología de La Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain; Universitat Rovira i Virgili, Institut D'Investigació Sanitària Pere i Virgili, Departament de Bioquímica i Biotecnologia, Unitat de Nutrició Humana, 43201 Reus, Spain.
Clin Nutr. 2023 Apr;42(4):477-485. doi: 10.1016/j.clnu.2023.02.004. Epub 2023 Feb 11.
BACKGROUND & AIMS: Higher consumption of coffee and caffeine has been linked to less weight gain and lower body mass index in prospective cohort studies. The aim of the study was to longitudinally assess the association of changes in coffee and caffeine intake with changes in fat tissue, in particular, visceral adipose tissue (VAT) using dual x-ray absorptiometry (DXA).
In the setting of a large, randomized trial of Mediterranean diet and physical activity intervention, we evaluated 1483 participants with metabolic syndrome (MetS). Repeated measurements of coffee consumption from validated food frequency questionnaires (FFQ) and DXA measurements of adipose tissue were collected at baseline, 6 months, 12 months and 3 years of follow-up. DXA-derived measurements of total and regional adipose tissue expressed as % of total body weight were transformed into sex-specific z-scores. Linear multilevel mixed-effect models were used to investigate the relationship between changes in coffee consumption and corresponding concurrent changes in fat tissue during a 3-year follow-up.
After adjustment for intervention group, and other potential confounders, an increase in caffeinated coffee consumption from no or infrequent consumption (≤3 cups/month) to moderate consumption (1-7 cups/week) was associated with reductions in total body fat (Δ z-score: -0.06; 95% CI: -0.11 to -0.02), trunk fat (Δ z-score: -0.07; 95% CI: -0.12 to -0.02), and VAT (Δ z-score: -0.07; 95% CI: -0.13 to -0.01). Neither changes from no or infrequent consumption to high levels of caffeinated coffee consumption (>1 cup/day) nor any changes in decaffeinated coffee consumption showed significant associations with changes in DXA measures.
Moderate changes in the consumption of caffeinated coffee, but not changes to high consumption, were associated with reductions in total body fat, trunk fat and VAT in a Mediterranean cohort with MetS. Decaffeinated coffee was not linked to adiposity indicators. Moderate consumption of caffeinated coffee may be part of a weight management strategy.
The trial was registered at the International Standard Randomized Controlled Trial (ISRCTN: http://www.isrctn.com/ISRCTN89898870) with number 89898870 and registration date of 24 July 2014, retrospectively registered.
在前瞻性队列研究中，较高的咖啡和咖啡因摄入量与较少的体重增加及较低的体重指数相关。本研究的目的是使用双能X线吸收法（DXA）纵向评估咖啡和咖啡因摄入量的变化与脂肪组织变化，特别是内脏脂肪组织（VAT）变化之间的关联。
在一项关于地中海饮食和体育活动干预的大型随机试验中，我们评估了1483名患有代谢综合征（MetS）的参与者。通过经过验证的食物频率问卷（FFQ）对咖啡摄入量进行重复测量，并在基线、随访6个月、12个月和3年时收集脂肪组织的DXA测量数据。将以体重百分比表示的全身和局部脂肪组织的DXA测量值转换为特定性别的z分数。使用线性多级混合效应模型研究在3年随访期间咖啡摄入量的变化与脂肪组织相应的同时变化之间的关系。
在对干预组和其他潜在混杂因素进行调整后，含咖啡因咖啡的摄入量从不饮用或很少饮用（≤3杯/月）增加到适量饮用（1 - 7杯/周）与全身脂肪减少（Δz分数：-0.06；95%置信区间：-0.11至-0.02）、躯干脂肪减少（Δz分数：-0.07；95%置信区间：-0.12至-0.02）和内脏脂肪组织减少（Δz分数：-0.07；95%置信区间：-0.13至-0.01）相关。从从不饮用或很少饮用增加到大量饮用含咖啡因咖啡（>1杯/天）的变化以及脱咖啡因咖啡摄入量的任何变化均未显示与DXA测量值的变化有显著关联。
在患有MetS的地中海队列中，含咖啡因咖啡摄入量的适度变化而非大量饮用的变化与全身脂肪、躯干脂肪和内脏脂肪组织的减少相关。脱咖啡因咖啡与肥胖指标无关。适度饮用含咖啡因咖啡可能是体重管理策略的一部分。
该试验在国际标准随机对照试验（ISRCTN：http://www.isrctn.com/ISRCTN89898870）注册，编号为89898870，注册日期为2014年7月24日，为回顾性注册。
