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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Stefek M, Benes L, Jergelová M, Scasnár V, Turi-Nagy L, Kocis P

Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Czechoslovakia.

Xenobiotica. 1987 Sep;17(9):1067-73. doi: 10.3109/00498258709044205.

The metabolism of stobadine, a gamma-carboline antiarrhythmic and cardioprotective agent, was investigated in vitro using fortified rat liver microsomal preparations. 2. Two metabolic products, N-desmethyl stobadine and stobadine N-oxide were isolated and identified by means of t.l.c.,g.l.c. -mass spectrometry, n.m.r. spectrometry and comparison with synthetic reference compounds. 3. Stobadine N-oxide was resolved into two optically active stereoisomers which were produced enzymically in approximately equal quantities.

使用强化大鼠肝微粒体制剂在体外研究了γ-咔啉类抗心律失常和心脏保护剂司托巴定的代谢。2. 通过薄层层析、气相色谱-质谱联用、核磁共振光谱以及与合成参考化合物比较，分离并鉴定了两种代谢产物，N-去甲基司托巴定和司托巴定N-氧化物。3. 司托巴定N-氧化物被拆分为两种光学活性立体异构体，它们是通过酶促反应以大致相等的量产生的。

Stefek M, Benes L, Jergelová M, Scasnár V, Turi-Nagy L, Kocis P

Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Czechoslovakia.

Xenobiotica. 1987 Sep;17(9):1067-73. doi: 10.3109/00498258709044205.

The metabolism of stobadine, a gamma-carboline antiarrhythmic and cardioprotective agent, was investigated in vitro using fortified rat liver microsomal preparations. 2. Two metabolic products, N-desmethyl stobadine and stobadine N-oxide were isolated and identified by means of t.l.c.,g.l.c. -mass spectrometry, n.m.r. spectrometry and comparison with synthetic reference compounds. 3. Stobadine N-oxide was resolved into two optically active stereoisomers which were produced enzymically in approximately equal quantities.

使用强化大鼠肝微粒体制剂在体外研究了γ-咔啉类抗心律失常和心脏保护剂司托巴定的代谢。2. 通过薄层层析、气相色谱-质谱联用、核磁共振光谱以及与合成参考化合物比较，分离并鉴定了两种代谢产物，N-去甲基司托巴定和司托巴定N-氧化物。3. 司托巴定N-氧化物被拆分为两种光学活性立体异构体，它们是通过酶促反应以大致相等的量产生的。