In vitro metabolism of 2-(5-ethylpyridin-2-yl)benzimidazole.
作者信息
Caputo O, Grosa G, Balliano G, Rocco F, Biglino G
机构信息
Istituto di Chimica Farmaceutica Applicata, Universita di Torino, Italy.
出版信息
Eur J Drug Metab Pharmacokinet. 1988 Jan-Mar;13(1):47-51. doi: 10.1007/BF03189928.
PMID:3260865
Abstract
The in vitro metabolic transformation of the anti-inflammatory agent 2-(5-ethylpyridin-2-yl)benzimidazole (KB-1043) was studied with phenobarbital and 3-methylcholanthrene induced rat liver microsomal fractions containing an NADPH-generating system. The major metabolite was a benzylic oxidation product and a secondary metabolite was also recovered. The metabolites were isolated by TLC and HPLC techniques and identified by comparison with known pure compounds.
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