Richard A. and Susan F. Smith Center for Outcomes Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.
Heart and Vascular Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
JAMA. 2023 Mar 21;329(11):899-909. doi: 10.1001/jama.2023.2307.
Declines in cardiovascular mortality have stagnated in the US over the past decade, in part related to worsening risk factor control in older adults. Little is known about how the prevalence, treatment, and control of cardiovascular risk factors have changed among young adults aged 20 to 44 years.
To determine if the prevalence of cardiovascular risk factors (hypertension, diabetes, hyperlipidemia, obesity, and tobacco use), treatment rates, and control changed among adults aged 20 to 44 years from 2009 through March 2020, overall and by sex and race and ethnicity.
DESIGN, SETTING, AND PARTICIPANTS: Serial cross-sectional analysis of adults aged 20 to 44 years in the US participating in the National Health and Nutrition Examination Survey (2009-2010 to 2017-March 2020).
National trends in the prevalence of hypertension, diabetes, hyperlipidemia, obesity, and smoking history; treatment rates for hypertension and diabetes; and blood pressure and glycemic control in those receiving treatment.
Among 12 924 US adults aged 20 to 44 years (mean age, 31.8 years; 50.6% women), the prevalence of hypertension was 9.3% (95% CI, 8.1%-10.5%) in 2009-2010 and 11.5% (95% CI, 9.6%-13.4%) in 2017-2020. The prevalence of diabetes (from 3.0% [95% CI, 2.2%-3.7%] to 4.1% [95% CI, 3.5%-4.7%]) and obesity (from 32.7% [95% CI, 30.1%-35.3%] to 40.9% [95% CI, 37.5%-44.3%]) increased from 2009-2010 to 2017-2020, while the prevalence of hyperlipidemia decreased (from 40.5% [95% CI, 38.6%-42.3%] to 36.1% [95% CI, 33.5%-38.7%]). Black adults had high rates of hypertension across the study period (2009-2010: 16.2% [95% CI, 14.0%-18.4%]; 2017-2020: 20.1% [95% CI, 16.8%-23.3%]), and significant increases in hypertension were observed among Mexican American adults (from 6.5% [95% CI, 5.0%-8.0%] to 9.5% [95% CI, 7.3%-11.7%]) and other Hispanic adults (from 4.4% [95% CI, 2.1%-6.8%] to 10.5% [95% CI, 6.8%-14.3%]), while Mexican American adults had a significant rise in diabetes (from 4.3% [95% CI, 2.3%-6.2%] to 7.5% [95% CI, 5.4%-9.6%]). The percentage of young adults treated for hypertension who achieved blood pressure control did not significantly change (from 65.0% [95% CI, 55.8%-74.2%] in 2009-2010 to 74.8% [95% CI, 67.5%-82.1%] in 2017-2020], while glycemic control among young adults receiving treatment for diabetes remained suboptimal throughout the study period (2009-2010: 45.5% [95% CI, 27.7%-63.3%]) to 2017-2020: 56.6% [95% CI, 39.2%-73.9%]).
In the US, diabetes and obesity increased among young adults from 2009 to March 2020, while hypertension did not change and hyperlipidemia declined. There was variation in trends by race and ethnicity.
在过去的十年中,美国心血管死亡率的下降已经停滞不前,部分原因是老年人的风险因素控制情况恶化。关于心血管风险因素(高血压、糖尿病、血脂异常、肥胖和吸烟)在 20 至 44 岁的年轻人中的流行程度、治疗率和控制情况如何变化,知之甚少。
确定从 2009 年至 2020 年 3 月,20 至 44 岁成年人的心血管风险因素(高血压、糖尿病、血脂异常、肥胖和吸烟史)的流行率、治疗率以及治疗组的控制情况是否发生了变化,整体情况以及按性别和种族和族裔进行了细分。
设计、地点和参与者:对美国 20 至 44 岁成年人进行的全国健康和营养调查(2009-2010 年至 2017 年 3 月 2020 年)的连续横断面分析。
高血压、糖尿病、血脂异常、肥胖和吸烟史的流行率;高血压和糖尿病的治疗率;以及接受治疗者的血压和血糖控制情况。
在 12924 名美国 20 至 44 岁成年人(平均年龄 31.8 岁;女性占 50.6%)中,2009-2010 年高血压的流行率为 9.3%(95%CI,8.1%-10.5%),2017-2020 年为 11.5%(95%CI,9.6%-13.4%)。糖尿病(从 3.0%(95%CI,2.2%-3.7%)至 4.1%(95%CI,3.5%-4.7%))和肥胖(从 32.7%(95%CI,30.1%-35.3%)至 40.9%(95%CI,37.5%-44.3%))的流行率从 2009-2010 年增加到 2017-2020 年,而血脂异常的流行率则从 40.5%(95%CI,38.6%-42.3%)降至 36.1%(95%CI,33.5%-38.7%)。在整个研究期间,黑人成年人的高血压发生率一直很高(2009-2010 年:16.2%(95%CI,14.0%-18.4%);2017-2020 年:20.1%(95%CI,16.8%-23.3%)),而墨西哥裔美国成年人(从 6.5%(95%CI,5.0%-8.0%)至 9.5%(95%CI,7.3%-11.7%))和其他西班牙裔美国人(从 4.4%(95%CI,2.1%-6.8%)至 10.5%(95%CI,6.8%-14.3%))的高血压发病率显著上升,而墨西哥裔美国人的糖尿病发病率则显著上升(从 4.3%(95%CI,2.3%-6.2%)至 7.5%(95%CI,5.4%-9.6%))。接受高血压治疗的年轻人中血压控制达标率没有显著变化(从 2009-2010 年的 65.0%(95%CI,55.8%-74.2%)至 2017-2020 年的 74.8%(95%CI,67.5%-82.1%)),而糖尿病患者的血糖控制情况在整个研究期间一直不理想(2009-2010 年:45.5%(95%CI,27.7%-63.3%)至 2017-2020 年:56.6%(95%CI,39.2%-73.9%))。
在美国,2009 年至 2020 年 3 月期间,年轻人的糖尿病和肥胖率有所上升,而高血压没有变化,血脂异常则有所下降。这些趋势在种族和族裔方面存在差异。