Mehlhorn J
Pathologisches Institut, MVB Karl-Marx-Stadt/Stollberg.
Z Urol Nephrol. 1987 Aug;80(8):441-7.
Systematic histological investigations concerning the latent carcinoma of the prostate gland were performed on macrosections by means of the serial section technique in 450 males between 40 and older than 80 years. The frequency was 29.6% with age-related increase of frequency. Unequivocally dominated uniform highly differentiated adenocarcinomas. An infiltration of the capsule was found in 65.4% and an infiltration of the perineural sheath in 42.8% of the cases, preferring the pluriform types of carcinomas. Hyperplastic lesions of the prostate gland with cellular atypias could be made evident in the latent carcinoma of the uniform type in 74% and in the pluriform type in 91.9% of the cases. The results emphasize the requirement of a careful and comprehensive investigation of the TUR-material by the pathologist, on the other hand they support the opinion of the occurrence of various types of carcinoma of the prostate gland with different morphogenesis and prognosis.
采用连续切片技术,对450名年龄在40岁至80岁以上的男性前列腺大体切片进行了有关前列腺潜伏癌的系统组织学研究。其发生率为29.6%,且随年龄增长而增加。明确以均匀的高分化腺癌为主。在65.4%的病例中发现有包膜浸润,42.8%的病例有神经周鞘浸润,多形性癌类型更易出现这种情况。在74%的均匀型潜伏癌病例和91.9%的多形性潜伏癌病例中,可发现伴有细胞异型性的前列腺增生性病变。这些结果强调了病理学家对经尿道切除标本进行仔细全面检查的必要性,另一方面,也支持了前列腺存在不同形态发生和预后的多种类型癌的观点。