Zrelak Patricia Ann
Patricia Zrelak, PhD, RN, NEA-BC, CNRN, SCRN, ASC-BC, CCRN-K, PHN, FAHA, is an epidemiologist and nurse researcher, currently working as a clinical practice consultant for Kaiser Permanente. She is nationally known for her work in stroke and patient safety.
J Christ Nurs. 2023;40(2):110-115. doi: 10.1097/CNJ.0000000000001047.
Although the first documented clinical trial as described in the biblical book of Daniel dates to 606 BC, the prophet Daniel's nutrition study is contemporary in both approach and topic and could be considered the first comparative effectiveness research (CER) trial. This article summarizes the historical evolution of clinical trials and associated regulatory legislation. Ethical considerations foundational to nursing and evidence-based practice (EBP) in the 21st century are examined. Distinguishing features of CER, various study designs and checklists, and EBP are detailed. Biblical foundations for research and the Bible's relevance to modern research methods are discussed.
尽管《圣经》中《但以理书》所记载的首个有文献记录的临床试验可追溯到公元前606年，但先知但以理的营养研究在方法和主题上都具有现代性，可被视为首个比较效果研究（CER）试验。本文总结了临床试验的历史演变以及相关的监管立法。审视了21世纪护理和循证实践（EBP）的基本伦理考量。详细介绍了CER的显著特征、各种研究设计和清单以及EBP。讨论了研究的圣经基础以及《圣经》与现代研究方法的相关性。
