Liggins Institute, University of Auckland, Auckland, New Zealand.
NCD Center of Excellence, Research Institute for Health Sciences, Chiang Mai University, Thailand.
Phys Occup Ther Pediatr. 2023;43(5):564-581. doi: 10.1080/01942638.2023.2181723. Epub 2023 Mar 5.
To evaluate the feasibility and acceptability of vibration therapy (VT) in preschool children with cerebral palsy (CP) and obtain preliminary data on its potential effectiveness. Nine children aged 2.5-4.8 years (4 boys) with CP GMFCS levels I-III participated in a single-group feasibility study, undergoing a 12-week control period without intervention, followed by 12 weeks of home-based VT (four times/week, 9 min/day, frequency 20 Hz). We assessed adherence to VT protocol, adverse events, and family acceptability of VT. Clinical assessments included motor function (GMFM-66), body composition (DXA), mobility (10-meter walk/run test), and health-related quality of life (PedsQL). VT was well tolerated and acceptable to families, with high adherence levels reported (mea 93%). There were no observed between-period differences (ΔControl vs ΔVT) except for an improvement in the PedsQL "Movement & Balance" dimension with VT (p = 0.044). Nonetheless, changes after the VT but not the Control period were suggestive of potential treatment benefits for mobility, gross motor function, and body composition (lean mass and legs bone mineral density). Home-based VT is feasible and acceptable for preschool children with CP. Our preliminary data suggest potential health benefits from VT for these children, supporting larger randomized trials to assess its effectiveness properly. Australian New Zealand Clinical Trials Registry (ACTRN12618002027291).
评估振动疗法（VT）在患有脑瘫（CP）的学龄前儿童中的可行性和可接受性，并获得其潜在疗效的初步数据。9 名年龄在 2.5-4.8 岁（4 名男孩）的 CP GMFCS 水平 I-III 的儿童参加了一项单组可行性研究，在没有干预的情况下进行了 12 周的对照期，随后进行了 12 周的家庭 VT（每周 4 次，每次 9 分钟，频率 20Hz）。我们评估了 VT 方案的依从性、不良事件和家庭对 VT 的可接受性。临床评估包括运动功能（GMFM-66）、身体成分（DXA）、移动能力（10 米步行/跑测试）和健康相关生活质量（PedsQL）。VT 耐受性良好，家庭接受度高，报告的依从率很高（均值 93%）。除了 VT 后“运动和平衡”维度的 PedsQL 改善（p=0.044）外，两个时期之间没有观察到差异（ΔControl vs ΔVT）。然而，VT 后而非对照期后的变化表明 VT 对移动能力、粗大运动功能和身体成分（瘦体重和腿部骨矿物质密度）可能具有治疗益处。家庭式 VT 对 CP 学龄前儿童是可行且可接受的。我们的初步数据表明，VT 对这些儿童可能具有健康益处，支持进行更大规模的随机试验以正确评估其疗效。澳大利亚和新西兰临床试验注册中心（ACTRN12618002027291）。
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