Srimati Kanuri Santhamma Center for Vitreo - Retinal Diseases, Anant Bajaj Retina Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India.
Allen Foster Community Eye Health Research Centre, Gullapalli Pratibha Rao International Centre for Advancement of Rural Eye care, L V Prasad Eye Institute; Brien Holden Eye Research Centre, L.V. Prasad Eye Institute, Banjara Hills, Hyderabad, India; School of Optometry and Vision Science, University of New South Wales, Sydney, Australia.
Indian J Ophthalmol. 2023 Mar;71(3):902-908. doi: 10.4103/ijo.IJO_1610_22.
To assess the incidence, visual impairment, and blindness due to retinitis pigmentosa (RP) in a rural southern Indian cohort.
This is a population-based longitudinal cohort study of participants with RP from the Andhra Pradesh Eye Disease Study (APEDS) cohorts I and III, respectively. The study included participants with RP of APEDS I who were followed until APEDS III. Their demographic data along with ocular features, fundus photographs, and visual fields (Humphrey) were collected. Descriptive statistics using mean ± standard deviation with interquartile range (IQR) were calculated. The main outcome measures were RP incidence, visual impairment, and blindness as per the World Health Organization (WHO) definitions.
At baseline (APEDS I), 7771 participants residing in three rural areas were examined. There were nine participants with RP with a mean age at baseline of 47.33 ± 10.89 years (IQR: 39-55). There was a male preponderance (6:3), and the mean best-corrected visual acuity (BCVA) of 18 eyes from nine participants with RP was 1.2 ± 0.72 logarithm of minimum angle of resolution (logMAR; IQR: 0.7-1.6). Over a mean follow-up duration of 15 years, 5395/7771 (69.4%) were re-examined, which included seven RP participants from APEDS 1. Additionally, two new participants with RP were identified; so, the overall incidence was 370/ million in 15 years (24.7/million per year). The mean BCVA of 14 eyes of seven participants with RP who were re-examined in APEDS III was 2.17 ± 0.56 logMAR (IQR: 1.8-2.6), and five of these seven participants with RP developed incident blindness during the follow-up period.
RP is a prevalent disease in southern India that warrants appropriate strategies to prevent this condition.
评估印度南部农村人群中视网膜色素变性（RP）的发病率、视力损害和失明情况。
这是一项基于人群的纵向队列研究，参与者来自安得拉邦眼病研究（APEDS）I 期和 III 期队列。该研究包括参加 APEDS I 期并随访至 APEDS III 期的 RP 患者。收集他们的人口统计学数据、眼部特征、眼底照片和视野（Humphrey）。使用平均值±标准差和四分位距（IQR）进行描述性统计。主要观察指标为世界卫生组织（WHO）定义的 RP 发病率、视力损害和失明。
在基线（APEDS I 期）时，对居住在三个农村地区的 7771 名参与者进行了检查。共有 9 名 RP 患者，其平均基线年龄为 47.33±10.89 岁（IQR：39-55）。男性居多（6:3），9 名 RP 患者的 18 只眼平均最佳矫正视力（BCVA）为 1.2±0.72 对数最小角分辨率（logMAR；IQR：0.7-1.6）。在平均 15 年的随访期间，对 7771 名中的 5395 名（69.4%）进行了再次检查，其中包括来自 APEDS I 的 7 名 RP 患者。此外，还发现了另外 2 名新的 RP 患者，因此，15 年内的总发病率为 370/百万，即每年 24.7/百万。在 APEDS III 中再次检查的 7 名 RP 患者的 14 只眼中，有 5 只眼的平均 BCVA 为 2.17±0.56 logMAR（IQR：1.8-2.6），这 7 名患者中有 5 名在随访期间发生了视力损害。
RP 在印度南部是一种常见疾病，需要制定适当的策略来预防这种疾病。
