镓和镥-奥曲肽在一例罕见的SSTR2和ESWR1-CREM融合阳性的肺未分化圆形细胞瘤中的成像与治疗
Imaging and treatment with Gallium and Lutetium-DOTATATE in a rare SSTR2 and ESWR1-CREM fusion positive undifferentiated round cell tumour of the lung.
作者信息
Kumaran Arjunan, Koo Si Xuan, Yeong Joe, Takano Angela Maria, Farid Mohamad, Loke Siu Hoong, Nei Wen Long
机构信息
Division of Radiation Oncology, National Cancer Centre, Singapore, Singapore.
Department of Nuclear Medicine & Molecular Imaging, Division of Radiological Sciences, Singapore General Hospital, Singapore, Singapore.
出版信息
BJR Case Rep. 2022 Nov 8;9(1):20220094. doi: 10.1259/bjrcr.20220094. eCollection 2023 Feb.
The authors present a 45-year-old lady with a rare undifferentiated round cell tumour of the lung with a ESWR1-CREM fusion gene that progressed despite multiple lines of therapy. The tumour was Somatostatin Receptors Type 2 (SSTR2) positive and avid on Gallium-DOTATATE imaging. This allowed for novel treatment with Peptide Receptor Radionuclide Therapy (PRRT) using Lutetium-DOTATATE after all other standard of care options were exhausted.
作者报告了一位45岁女性，患有罕见的肺未分化圆形细胞瘤，带有ESWR1-CREM融合基因，尽管接受了多线治疗仍进展。该肿瘤为2型生长抑素受体（SSTR2）阳性，在镓- DOTATATE显像上摄取良好。在所有其他标准治疗方案均无效后，这使得可以使用镥- DOTATATE进行肽受体放射性核素治疗（PRRT）的新型治疗。
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