Signes-Pastor Antonio J, Sayarath Vicki, Jackson Brian, Cottingham Kathryn L, Punshon Tracy, Karagas Margaret R
Department of Epidemiology, Geisel Medical School at Dartmouth College, Lebanon, NH USA.
Instituto de Investigación Sanitaria y Biomédica de Alicante, Universidad Miguel Hernández (ISABIAL-UMH), Alicante, Spain.
Expo Health. 2023;15(1):269-279. doi: 10.1007/s12403-022-00489-x. Epub 2022 Jun 16.
Even the low levels of non-essential elements exposure common in the US may have health consequences especially early in life. However, little is known about the infant's dynamic exposure to essential and non-essential elements. This study aims to evaluate exposure to essential and non-essential elements during infants' first year of life and to explore the association between the exposure and rice consumption. Paired urine samples from infants enrolled in the New Hampshire Birth Cohort Study (NHBCS) were collected at approximately 6 weeks (exclusively breastfed) and at 1 year of age after weaning ( = 187). A further independent subgroup of NHBCS infants with details about rice consumption at 1 year of age also was included ( = 147). Urinary concentrations of 8 essential (Co, Cr, Cu, Fe, Mn, Mo, Ni, and Se) and 9 non-essential (Al, As, Cd, Hg, Pb, Sb, Sn, V, and U) elements were determined as a measure of exposure. Several essential (Co, Fe, Mo, Ni, and Se) and non-essential (Al, As, Cd, Hg, Pb, Sb, Sn, and V) elements had higher concentrations at 1 year than at 6 weeks of age. The highest increases were for urinary As and Mo with median concentrations of 0.20 and 1.02 µg/L at 6 weeks and 2.31 and 45.36 µg/L at 1 year of age, respectively. At 1 year of age, As and Mo urine concentrations were related to rice consumption. Further efforts are necessary to minimize exposure to non-essential elements while retaining essential elements to protect and promote children's health.
The online version contains supplementary material available at 10.1007/s12403-022-00489-x.
即使是美国常见的低水平非必需元素暴露也可能对健康产生影响，尤其是在生命早期。然而，对于婴儿对必需和非必需元素的动态暴露情况知之甚少。本研究旨在评估婴儿出生后第一年对必需和非必需元素的暴露情况，并探讨这种暴露与大米消费之间的关联。从新罕布什尔州出生队列研究（NHBCS）中招募的婴儿，在大约6周龄（纯母乳喂养）和断奶后1岁时（n = 187）采集配对的尿液样本。还纳入了NHBCS婴儿的一个独立亚组，该亚组提供了1岁时大米消费的详细信息（n = 147）。测定尿液中8种必需元素（钴、铬、铜、铁、锰、钼、镍和硒）和9种非必需元素（铝、砷、镉、汞、铅、锑、锡、钒和铀）的浓度，作为暴露的衡量指标。几种必需元素（钴、铁、钼、镍和硒）和非必需元素（铝、砷、镉、汞、铅、锑、锡和钒）在1岁时的浓度高于6周龄时。增幅最大的是尿砷和钼，6周龄时中位数浓度分别为0.20和1.02μg/L，1岁时分别为2.31和45.36μg/L。在1岁时，尿砷和钼的浓度与大米消费有关。有必要进一步努力，在保留必需元素的同时尽量减少非必需元素的暴露，以保护和促进儿童健康。
在线版本包含可在10.1007/s12403-022-00489-x获取的补充材料。
