Area of Cardiometabolic and Renal Risk, Biomedical Research Institute Hospital Clinic of Valencia (INCLIVA), Valencia, Spain; Department of Statistics and Operational Research, University of Valencia, Valencia, Spain; Department of Environmental Health Sciences, Columbia University, New York, USA.
Area of Cardiometabolic and Renal Risk, Biomedical Research Institute Hospital Clinic of Valencia (INCLIVA), Valencia, Spain; Department of Statistics and Operational Research, University of Valencia, Valencia, Spain; Department of Environmental Health Sciences, Columbia University, New York, USA.
Environ Int. 2019 Feb;123:171-180. doi: 10.1016/j.envint.2018.11.055. Epub 2018 Dec 5.
Few studies have investigated the role of exposure to metals and metal mixtures on oxidative stress in the general population.
We evaluated the cross-sectional association of urinary metal and metal mixtures with urinary oxidative stress biomarkers, including oxidized to reduced glutathione ratio (GSSG/GSH), malondialdehyde (MDA), and 8‑oxo‑7,8‑dihydroguanine (8-oxo-dG), in a representative sample of a general population from Spain (Hortega Study).
Urine antimony (Sb), barium (Ba), cadmium (Cd), chromium (Cr), cobalt (Co), copper (Cu), molybdenum (Mo), vanadium (V) and zinc (Zn) were measured by ICPMS in 1440 Hortega Study participants.
The geometric mean ratios (GMRs) of GSSG/GSH comparing the 80th to the 20th percentiles of metal distributions were 1.15 (95% confidence intervals [95% CI]: 1.03-1.27) for Mo, 1.17 (1.05-1.31) for Ba, 1.23 (1.04-1.46) for Cr and 1.18 (1.00-1.40) for V. For MDA, the corresponding GMRs (95% CI) were 1.13 (1.03-1.24) for Zn and 1.12 (1.02-1.23) for Cd. In 8-oxo-dG models, the corresponding GMR (95% CI) were 1.12 (1.01-1.23) for Zn and 1.09 (0.99-1.20) for Cd. Cr for GSSG/GSH and Zn for MDA and 8-oxo-dG drove most of the observed associations. Principal component (PC) 1 (largely reflecting non-essential metals) was positively associated with GSSG/GSH. The association of PC2 (largely reflecting essential metals) was positive for GSSG/GSH but inverse for MDA.
Urine Ba, Cd, Cr, Mo, V and Zn were positively associated with oxidative stress measures at metal exposure levels relevant for the general population. The potential health consequences of environmental, including nutritional, exposure to these metals warrants further investigation.
很少有研究调查金属和金属混合物暴露对普通人群氧化应激的作用。
我们评估了尿中金属和金属混合物与尿氧化应激生物标志物的横断面关联，包括氧化型与还原型谷胱甘肽比（GSSG/GSH）、丙二醛（MDA）和 8-氧-7,8-二氢鸟嘌呤（8-oxo-dG），在西班牙一般人群的代表性样本（Hortega 研究）中。
在 1440 名 Hortega 研究参与者中，通过 ICPMS 测量了尿中的锑（Sb）、钡（Ba）、镉（Cd）、铬（Cr）、钴（Co）、铜（Cu）、钼（Mo）、钒（V）和锌（Zn）。
GSSG/GSH 的几何平均比（GMR）比较金属分布第 80 百分位数与第 20 百分位数，Mo 的 GMR 为 1.15（95%置信区间[95%CI]：1.03-1.27），Ba 为 1.17（1.05-1.31），Cr 为 1.23（1.04-1.46），V 为 1.18（1.00-1.40）。对于 MDA，相应的 GMR（95%CI）分别为 1.13（1.03-1.24）的 Zn 和 1.12（1.02-1.23）的 Cd。在 8-oxo-dG 模型中，相应的 GMR（95%CI）分别为 1.12（1.01-1.23）的 Zn 和 1.09（0.99-1.20）的 Cd。GSSG/GSH 中的 Cr 和 MDA 中的 Zn 以及 8-oxo-dG 驱动了观察到的大部分关联。主成分（PC）1（主要反映非必需金属）与 GSSG/GSH 呈正相关。PC2（主要反映必需金属）与 GSSG/GSH 呈正相关，但与 MDA 呈负相关。
尿中 Ba、Cd、Cr、Mo、V 和 Zn 与氧化应激标志物呈正相关，其金属暴露水平与普通人群相关。环境（包括营养）暴露于这些金属对健康的潜在影响需要进一步研究。
