Tian Kaijiang, Yang Yu, Zhou Kun, Deng Nianhua, Tian Zhen, Wu Zefan, Liu Xiyan, Zhang Fan, Jiang Zhisheng
The First Affiliated Hospital of Hebei North University, Zhangjiakou, China.
Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province, University of South China, Hengyang, China.
Front Cardiovasc Med. 2023 Feb 16;10:1116509. doi: 10.3389/fcvm.2023.1116509. eCollection 2023.
Cardiovascular disease (CVD) is the number one cause of death in the world and seriously threatens human health. Pyroptosis is a new type of cell death discovered in recent years. Several studies have revealed that ROS-induced pyroptosis plays a key role in CVD. However, the signaling pathway ROS-induced pyroptosis has yet to be fully understood. This article reviews the specific mechanism of ROS-mediated pyroptosis in vascular endothelial cells, macrophages, and cardiomyocytes. Current evidence shows that ROS-mediated pyroptosis is a new target for the prevention and treatment of cardiovascular diseases such as atherosclerosis (AS), myocardial ischemia-reperfusion injury (MIRI), and heart failure (HF).
心血管疾病（CVD）是全球头号死因，严重威胁人类健康。细胞焦亡是近年来发现的一种新型细胞死亡方式。多项研究表明，活性氧（ROS）诱导的细胞焦亡在心血管疾病中起关键作用。然而，ROS诱导细胞焦亡的信号通路尚未完全明确。本文综述了ROS介导的细胞焦亡在血管内皮细胞、巨噬细胞和心肌细胞中的具体机制。目前的证据表明，ROS介导的细胞焦亡是动脉粥样硬化（AS）、心肌缺血再灌注损伤（MIRI）和心力衰竭（HF）等心血管疾病防治的新靶点。
