Kishimoto Shinji, Oda Nozomu, Maruhashi Tatsuya, Tanigawa Shunsuke, Mizobuchi Aya, Yusoff Farina Mohamad, Fujita Asuka, Uchiki Toshio, Kajikawa Masato, Yoshimura Kenichi, Yamaji Takayuki, Harada Takahiro, Hashimoto Yu, Nakano Yukiko, Hirota Seiko, Yoshinaga Shinji, Goto Chikara, Nakashima Ayumu, Higashi Yukihito
Department of Regenerative Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Department of Cardiovascular Medicine, Hiroshima Red Cross Hospital and Atomic-Bomb Survivors Hospital, Hiroshima, Japan.
Front Cardiovasc Med. 2023 Feb 17;10:1122794. doi: 10.3389/fcvm.2023.1122794. eCollection 2023.
The purpose of this study was to evaluate the effects of exposure to radiation caused by an atomic bomb in atomic bomb survivors on vascular function and vascular structure and to evaluate the relationships of radiation dose from the atomic bomb with vascular function and vascular structure in atomic bomb survivors.
Flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation (NID) as indices of vascular function, brachial-ankle pulse wave velocity (baPWV) as an index of vascular function and vascular structure, and brachial artery intima-media thickness (IMT) as an index of vascular structure were measured in 131 atomic bomb survivors and 1,153 control subjects who were not exposed to the atomic bomb. Ten of the 131 atomic bomb survivors with estimated radiation dose in a cohort study of Atomic Bomb Survivors in Hiroshima were enrolled in the study to evaluate the relationships of radiation dose from the atomic bomb with vascular function and vascular structure.
There was no significant difference in FMD, NID, baPWV, or brachial artery IMT between control subjects and atomic bomb survivors. After adjustment of confounding factors, there was still no significant difference in FMD, NID, baPWV, or brachial artery IMT between control subjects and atomic bomb survivors. Radiation dose from the atomic bomb was negatively correlated with FMD (ρ = -0.73, = 0.02), whereas radiation dose was not correlated with NID, baPWV or brachial artery IMT.
There were no significant differences in vascular function and vascular structure between control subjects and atomic bomb survivors. Radiation dose from the atomic bomb might be negatively correlated with endothelial function.
本研究旨在评估原子弹爆炸幸存者遭受辐射对血管功能和血管结构的影响，并评估原子弹辐射剂量与原子弹爆炸幸存者血管功能和血管结构之间的关系。
对131名原子弹爆炸幸存者和1153名未遭受原子弹爆炸辐射的对照者进行检测，分别以血流介导的血管舒张功能（FMD）和硝酸甘油诱导的血管舒张功能（NID）作为血管功能指标，以臂踝脉搏波速度（baPWV）作为血管功能和血管结构指标，以肱动脉内膜中层厚度（IMT）作为血管结构指标。在广岛原子弹爆炸幸存者队列研究中，选取131名估计有辐射剂量的原子弹爆炸幸存者中的10名，以评估原子弹辐射剂量与血管功能和血管结构之间的关系。
对照者与原子弹爆炸幸存者在FMD、NID、baPWV或肱动脉IMT方面无显著差异。在调整混杂因素后，对照者与原子弹爆炸幸存者在FMD、NID、baPWV或肱动脉IMT方面仍无显著差异。原子弹辐射剂量与FMD呈负相关（ρ = -0.73，P = 0.02），而辐射剂量与NID、baPWV或肱动脉IMT无相关性。
对照者与原子弹爆炸幸存者在血管功能和血管结构方面无显著差异。原子弹辐射剂量可能与内皮功能呈负相关。
