Wu Jing, Huang Lan, Wu Airong, Xu Jianlei, Wu Zhenghong, Le Meihua, Jiang Chenghua, Wu Hengjing
Clinical Center for Intelligent Rehabilitation Research, Shanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China.
School of Nursing, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Heliyon. 2023 Feb 17;9(3):e13841. doi: 10.1016/j.heliyon.2023.e13841. eCollection 2023 Mar.
There is limited information about coronary heart disease (CHD) in adults with physical disabilities. This study was performed to assess the incidence and predictors of the new development of CHD in adults with physical disabilities.
A retrospective cohort study was performed on 3902 physically disabled people in Shanghai, China. Baseline information was collected in January 2012, and participants were followed-up with for 7.5 years for CHD events. Risk factors for demographic characteristics, disease history, electrocardiography, and blood biochemical indicators were evaluated using a Cox proportional hazard model. Subgroup analyzes were performed according to gender and level of physical disability.
Out of the total 3902 adults with physical disabilities (average age 55.9 ± 8.5 years), 468 (12.0%) developed CHD, during a median follow-up period of 7 years. Independent predictors of CHD included the following: age (HR = 1.411, 95% CI = 1.255-1.587, ＜0.001), gender (HR = 0.773, 95% CI = 0.637-0.940, = 0.010), abnormal electrocardiogram(HR = 1.396, 95% CI = 1.088-1.792, = 0.009), hypertension (HR = 1.657, 95% CI = 1.369-2.006, ＜0.001), diabetes (HR = 1.649, 95% CI = 1.307-2.081, ＜0.001), serum uric acid (HR = 1.001, 95% CI = 1.000-1.002, = 0.046), and total cholesterol (HR = 1.416, 95% CI = 1.054-1.902, = 0.021). In addition to the risk factors of the total population with physical disability, triglyceride was also a significant risk factor for CHD in the subgroup with women and mild disability.
During a 7.5 years period, the CHD incidence rate among physically disabled people was 12.0%. We identified the role of CHD risk factors such as age, gender, hypertension, diabetes, serum uric acid, total cholesterol, and abnormal electrocardiogram.
关于身体残疾成年人冠心病（CHD）的信息有限。本研究旨在评估身体残疾成年人冠心病新发的发病率及预测因素。
对中国上海3902名身体残疾者进行回顾性队列研究。2012年1月收集基线信息，并对参与者进行7.5年的冠心病事件随访。使用Cox比例风险模型评估人口统计学特征、病史、心电图和血液生化指标的危险因素。根据性别和身体残疾程度进行亚组分析。
在总共3902名身体残疾成年人（平均年龄55.9±8.5岁）中，在中位随访期7年期间，468人（12.0%）发生了冠心病。冠心病的独立预测因素包括：年龄（HR = 1.411，95%CI = 1.255 - 1.587，＜0.001）、性别（HR = 0.773，95%CI = 0.637 - 0.940，= 0.010）、心电图异常（HR = 1.396，95%CI = 1.088 - 1.792，= 0.009）、高血压（HR = 1.657，95%CI = 1.369 - 2.006，＜0.001）、糖尿病（HR = 1.649，95%CI = 1.307 - 2.081，＜0.001）、血清尿酸（HR = 1.001，95%CI = 1.000 - 1.002，= 0.046）和总胆固醇（HR = 1.416，95%CI = 1.054 - 1.902，= 0.021）。除了身体残疾总人口的危险因素外，甘油三酯也是女性和轻度残疾亚组中冠心病的重要危险因素。
在7.5年期间，身体残疾者的冠心病发病率为12.0%。我们确定了年龄、性别、高血压、糖尿病、血清尿酸、总胆固醇和心电图异常等冠心病危险因素的作用。
