光遗传学恢复线粒体膜电位能延长寿命。
Optogenetic rejuvenation of mitochondrial membrane potential extends lifespan.
机构信息
University of Washington, Department of Laboratory Medicine & Pathology, Seattle WA, 98195, United States of America.
University of Rochester Medical Center, Department of Anesthesiology and Perioperative Medicine, 575 Elmwood Ave., Rochester NY, 14642 Box 711/604. United States of America.
出版信息
Nat Aging. 2023 Feb;3(2):157-161. doi: 10.1038/s43587-022-00340-7. Epub 2022 Dec 30.
Abstract
Mitochondrial dysfunction plays a central role in aging but the exact biological causes are still being determined. Here, we show that optogenetically increasing mitochondrial membrane potential during adulthood using a light-activated proton pump improves age-associated phenotypes and extends lifespan in . Our findings provide direct causal evidence that rescuing the age-related decline in mitochondrial membrane potential is sufficient to slow the rate of aging and extend healthspan and lifespan.
摘要
线粒体功能障碍在衰老中起着核心作用，但确切的生物学原因仍在确定之中。在这里，我们表明，成年期使用光激活质子泵来增加线粒体膜电位可以改善与年龄相关的表型并延长寿命。我们的发现提供了直接的因果证据，表明挽救与年龄相关的线粒体膜电位下降足以减缓衰老速度并延长健康寿命和寿命。
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