Department of Thoracic Surgery, Chengdu Seventh People's Hospital, Chengdu, 610200 Sichuan, China.
Department of Oncology, Chengdu Seventh People's Hospital, Chengdu, 610200 Sichuan, China.
Comput Math Methods Med. 2023 Feb 23;2023:7550317. doi: 10.1155/2023/7550317. eCollection 2023.
Clinically, there were few reports on single-hole thoracoscopic segmental resection in non-small-cell lung cancer (NSCLC), and no report on the comparison of single-hole and three-hole thoracoscopic segmental resection. Hence, the purpose of the study was to explore the perioperative role of single-port thoracoscopic segmentectomy and three-port thoracoscopic segmentectomy for early-stage NSCLC.
The clinical data of 80 patients with early-stage NSCLC who were treated in our hospital from January 2021 to June 2022 were selected as the retrospective research subjects and divided into a comparison/research group with 40 cases in each group according to different surgical methods. Among them, the comparison group was received three-port thoracoscopic segmentectomy, and the research group was received single-port thoracoscopic segmentectomy. The surgical indicators, immune and tumor marker levels, as well as prognostic complications between two groups were compared.
There was no remarkable diversity between the two groups in terms of operation time and the number of lymph nodes dissected during the operation ( > 0.05). The surgical blood loss in research group was lower than comparison group ( < 0.05). After treatment, the levels of CYFRA21-1, CA125, as well as VGEF in the research group were markedly lower than comparison group ( < 0.05). The differences in CD, CD, and CD/CD after treatment were prominent, and the research group was higher than comparison group ( < 0.05). There was no statistical difference in postoperative complications between the two groups ( > 0.05).
Single-hole thoracoscopic lobectomy has obvious advantages in the treatment of NSCLC, which can reduce intraoperative bleeding, enhance the recovery of patients' immune function, and promote postoperative recovery.
临床上，非小细胞肺癌（NSCLC）单孔胸腔镜肺段切除术的报道较少，尚无单孔与三孔胸腔镜肺段切除术对比的报道。因此，本研究旨在探讨单孔与三孔胸腔镜肺段切除术治疗早期 NSCLC 的围手术期作用。
选取我院 2021 年 1 月至 2022 年 6 月收治的 80 例早期 NSCLC 患者的临床资料进行回顾性研究，根据手术方式的不同分为比较/研究组，每组 40 例。其中比较组行三孔胸腔镜肺段切除术，研究组行单孔胸腔镜肺段切除术。比较两组手术指标、免疫及肿瘤标志物水平和预后并发症。
两组患者的手术时间、术中淋巴结清扫数目比较，差异无统计学意义（>0.05）。研究组手术出血量低于比较组（<0.05）。治疗后，研究组的 CYFRA21-1、CA125、VEGF 水平均低于比较组（<0.05）。治疗后两组的 CD、CD、CD/CD 水平差异显著，且研究组高于比较组（<0.05）。两组患者术后并发症发生率比较，差异无统计学意义（>0.05）。
单孔胸腔镜肺段切除术治疗 NSCLC 具有明显优势，可减少术中出血量，增强患者的免疫功能恢复，促进术后康复。
