Liu Junyang, Chen Hang, Wang Min, He Wangjin, Yan Jia-Lei
Innovation Center of Marine Biotechnology and Pharmaceuticals, School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, China.
State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, China.
Front Chem. 2023 Feb 16;11:1132025. doi: 10.3389/fchem.2023.1132025. eCollection 2023.
P-chirality broadly appears in natural and synthetic functional molecules. The catalytic synthesis of organophosphorus compounds bearing P-stereogenic centers is still challenging, due to the lack of efficient catalytic systems. This review summarizes the key achievements in organocatalytic methodologies for the synthesis of P-stereogenic molecules. Different catalytic systems are emphasized for each strategy class (desymmetrization, kinetic resolution, and dynamic kinetic resolution) with examples cited to illustrate the potential applications of the accessed P-stereogenic organophosphorus compounds.
P-手性广泛存在于天然和合成功能分子中。由于缺乏高效的催化体系，催化合成含有P-手性中心的有机磷化合物仍然具有挑战性。本文综述了有机催化方法在合成P-手性分子方面的关键成果。针对每种策略类型（去对称化、动力学拆分和动态动力学拆分）重点介绍了不同的催化体系，并列举实例来说明所得到的P-手性有机磷化合物的潜在应用。
