Neumann F
Postgrad Med J. 1978;54 Suppl 2:11-24.
Substances described as progestogens differ greatly in their additional properties, which determine the limitations of their clinical use. The extrapolation of animal assays to human use requires caution, since synergism with oestrogens, which is usually necessary, shows widely-differing species-specific ratios. In other ratios, progestogens are often antagonistic to oestrogens.
被描述为孕激素的物质在其附加特性上差异很大，这些特性决定了它们临床应用的局限性。将动物试验结果外推至人类应用时需要谨慎，因为与雌激素的协同作用（这通常是必要的）在不同物种间的比例差异很大。在其他比例关系中，孕激素往往与雌激素相互拮抗。
