Svensson O, Reinholt F P, Engfeldt B
Department of Orthopaedic Surgery, Karolinska Institute, Huddinge University Hospital, Sweden.
Acta Pathol Microbiol Immunol Scand A. 1987 Nov;95(6):309-14. doi: 10.1111/j.1699-0463.1987.tb00046_95a.x.
Rickets can be induced by oral administration of metals. A depressive effect exerted by metal ions on the parathyroid gland has previously been suggested to be a pathogenetic factor in strontium-induced rickets. In the present investigation, rickets was induced in young rats by oral administration of strontium and manganese, respectively. The parathyroids were fixed by perfusion and the total volume of the parathyroid glands was determined by serial sectioning. Conventional stereological techniques were applied on the ultrastructural level and the densities obtained could be related to the total mass of parathyroid tissue. In both rachitic groups the volume of the parathyroid glands as well as the absolute amounts of all cellular components studied, were reduced. All these changes were, however, correlated to the decreased body weight of the experimental animals. This is well in line with the finding of unaltered serum concentrations of calcium and immunoreactive parathyroid hormone. Therefore, it is concluded that the parathyroids do not play an important role in the pathogenesis of metal rickets.
口服金属可诱发佝偻病。此前有人提出，金属离子对甲状旁腺的抑制作用是锶诱导佝偻病的发病因素。在本研究中，分别通过口服锶和锰在幼鼠中诱发佝偻病。通过灌注固定甲状旁腺，并通过连续切片确定甲状旁腺的总体积。在超微结构水平上应用传统的体视学技术，所获得的密度可与甲状旁腺组织的总质量相关。在两个佝偻病组中，甲状旁腺的体积以及所研究的所有细胞成分的绝对量均减少。然而，所有这些变化都与实验动物体重的减轻有关。这与血清钙和免疫反应性甲状旁腺激素浓度未改变的发现一致。因此，得出结论，甲状旁腺在金属性佝偻病的发病机制中不发挥重要作用。
