Svensson O, Hjerpe A, Reinholt F P, Wikström B, Engfeldt B
Acta Pathol Microbiol Immunol Scand A. 1985 May;93(3):115-20. doi: 10.1111/j.1699-0463.1985.tb03929.x.
The effect of Strontium (Sr) and Manganese (Mn) was studied on freshly isolated chondrocytes obtained from costal cartilage of young male rats. Cells isolated from rats rendered rachitic by oral exposure to Sr or Mn exhibited a decreased synthesis of glycosaminoglycans and collagen as judged by incorporation of 35SO4 and 3H proline. In vitro exposure of chondrocytes from untreated (control) animals to Sr or Mn at concentrations comparable to those found in cartilage from Sr and Mn rachitic rats, lowered the O2 consumption in both groups, but only Sr had any influence on the other parameters studied.
研究了锶（Sr）和锰（Mn）对从年轻雄性大鼠肋软骨中新鲜分离的软骨细胞的影响。通过口服暴露于Sr或Mn使大鼠患佝偻病，从这些大鼠分离出的细胞，根据35SO4和3H脯氨酸的掺入情况判断，其糖胺聚糖和胶原蛋白的合成减少。将未处理（对照）动物的软骨细胞在体外暴露于与患佝偻病的Sr和Mn大鼠软骨中发现的浓度相当的Sr或Mn，两组的氧气消耗量均降低，但只有Sr对所研究的其他参数有任何影响。
