Ream Sarah, Natarajan Piruthiviraj, Gupta Shruti, Sotelo-Rafiq Elsa, Schuller Dan
Department of Internal Medicine, Texas Tech University Health Sciences Center El Paso, Paul L. Foster School of Medicine, El Paso, USA.
Department of Internal Medicine, The Hospitals of Providence- Transmountain/Texas Tech University Health Sciences Center El Paso, Paul L. Foster School of Medicine, El Paso, USA.
Cureus. 2023 Jan 30;15(1):e34386. doi: 10.7759/cureus.34386. eCollection 2023 Jan.
It is well-documented that lung and bronchus cancers are the leading cause of cancer death in the United States in both male and female patients, with lung adenocarcinoma accounting for the highest prevalence of lung cancers. Significant eosinophilia in the setting of lung adenocarcinoma has been documented in a few reports, being described as a rare paraneoplastic syndrome. We report on an 81-year-old female with hypereosinophilia-associated lung adenocarcinoma. A chest film showed a right lung mass, which was not apparent on a chest film 1 year prior, in the setting of significant leukocytosis of 27.90 x 10/mm with eosinophilia of 6.40 x 10/mm. A computed tomography (CT) chest, obtained during admission, demonstrated significant right lower lobe mass enlargement since the previous study completed 5 months prior, with new occlusion of bronchi and pulmonary vessels to the region of the mass. Our observations are consistent with prior reports showing that the presence of eosinophilia in lung cancers may indicate rapid disease progression.
有充分的文献记载，肺癌和支气管癌是美国男性和女性癌症死亡的主要原因，其中肺腺癌在肺癌中所占比例最高。少数报告记录了肺腺癌患者出现显著嗜酸性粒细胞增多的情况，被描述为一种罕见的副肿瘤综合征。我们报告了一例81岁患有嗜酸性粒细胞增多相关肺腺癌的女性患者。胸部X光片显示右肺有肿块，1年前的胸部X光片上未显示，当时白细胞显著增多至27.90×10⁹/mm³，嗜酸性粒细胞为6.40×10⁹/mm³。入院时进行的胸部计算机断层扫描（CT）显示，自5个月前完成的上一次检查以来，右下叶肿块显著增大，肿块区域出现新的支气管和肺血管阻塞。我们的观察结果与之前的报告一致，表明肺癌中嗜酸性粒细胞增多可能预示疾病进展迅速。
