Department of Medicine, Heart, Lung and Esophageal Surgery Institute, University of Pittsuburgh, Pittsburgh, PA 15232, USA.
Am J Respir Crit Care Med. 2012 Jan 1;185(1):85-9. doi: 10.1164/rccm.201107-1223OC.
As computed tomography (CT) screening for lung cancer becomes more widespread, volumetric analyses, including doubling times, of CT-screen detected lung nodules and lung cancers may provide useful information in the follow-up and management of CT-detected lung nodules and cancers.
To analyze doubling times in CT screen detected lung cancers and compare prevalent and nonprevalent cancers and different cell types on non small cell lung cancer.
We performed volumetric and doubling time analysis on 63 non–small cell lung cancers detected as part of the Pittsburgh Lung Screening Study using a commercially available VITREA 2 workstation and VITREA VITAL nodule segmentation software.
Doubling times (DT) were divided into three groups: rapid (DT<183 d), typical (DT 183–365 d), and slow (DT>365 d). Adenocarcinoma/bronchioloalveolar carcinoma comprised 86.7% of the slow DT group compared with 20% of the rapid DT group. Conversely, squamous cell cancer comprised 60% of the rapid DT group compared with 3.3% of the slow DT group. Twenty-eight of 42 (67%) prevalent and 2 of 21 (10%) nonprevalent cancers were in the slow DT group (P<0.0001; Fisher's exact test). Twenty-four of 32 (75%) prevalent and 1 of 11 (9%) nonprevalent adenocarcinomas were in the slow DT group (P<0.0002; Fisher's exact test).
Volumetric analysis of CT-detected lung cancers is particularly useful in AC/BAC. Prevalent cancers have a significantly slower DT than nonprevalent cancers and a higher percentage of adenocarcinoma/bronchioloalveolar carcinoma. These results should affect the management of indeterminant lung nodules detected on screening CT scans.
随着计算机断层扫描（CT）肺癌筛查的广泛开展，CT 筛查发现的肺结节和肺癌的体积分析，包括倍增时间，可能为 CT 筛查发现的肺结节和癌症的随访和管理提供有用的信息。
分析 CT 筛查发现的肺癌的倍增时间，并比较非小细胞肺癌中常见和非常见癌症以及不同细胞类型的倍增时间。
我们对作为匹兹堡肺癌筛查研究一部分而发现的 63 例非小细胞肺癌进行了体积和倍增时间分析，使用了商用的 VITREA 2 工作站和 VITREA VITAL 结节分割软件。
倍增时间（DT）分为三组：快速（DT<183d）、典型（DT 183-365d）和缓慢（DT>365d）。缓慢 DT 组中腺癌/细支气管肺泡癌占 86.7%，而快速 DT 组中仅占 20%。相反，鳞状细胞癌在快速 DT 组中占 60%，而在缓慢 DT 组中仅占 3.3%。42 例（67%）常见癌症中有 28 例和 21 例（10%）非常见癌症中有 2 例为缓慢 DT 组（P<0.0001；Fisher 确切检验）。32 例常见腺癌中有 24 例和 11 例非常见腺癌中有 1 例为缓慢 DT 组（P<0.0002；Fisher 确切检验）。
CT 检测肺癌的体积分析在 AC/BAC 中尤为有用。常见癌症的 DT 明显比非常见癌症慢，腺癌/细支气管肺泡癌的比例更高。这些结果应影响对筛查 CT 扫描发现的不确定肺结节的管理。
