大脑另一侧之旅：慢性轻度或中度创伤性脑损伤患者的不对称性
Journey to the other side of the brain: asymmetry in patients with chronic mild or moderate traumatic brain injury.
作者信息
Ross David E, Seabaugh John D, Seabaugh Jan M, Alvarez Claudia, Ellis Laura Peyton, Powell Christopher, Reese Christopher, Cooper Leah, Shepherd Katherine, Alzheimer's Disease Neuroimaging Initiative For The
机构信息
Virginia Institute of Neuropsychiatry, Midlothian, VA 23114, USA.
Neuroscience Department, Randolph Macon College, Ashland, VA 23005, USA.
出版信息
Concussion. 2023 Jan 31;8(1):CNC101. doi: 10.2217/cnc-2022-0003. eCollection 2022 Dec.
AIM
Patients with chronic mild or moderate traumatic brain injury have some regions of brain atrophy (including cerebral white matter) but even more regions of abnormal brain enlargement (including other cerebral regions).
HYPOTHESIS
Ipsilateral injury and atrophy cause the eventual development of contralateral compensatory hypertrophy.
MATERIALS & METHODS: 50 patients with mild or moderate traumatic brain injury were compared to 80 normal controls (n = 80) with respect to MRI brain volume asymmetry. Asymmetry-based correlations were used to test the primary hypothesis.
RESULTS
The group of patients had multiple regions of abnormal asymmetry.
CONCLUSION
The correlational analyses supported the conclusion that acute injury to ipsilateral cerebral white matter regions caused atrophy, leading eventually to abnormal enlargement of contralateral regions due to compensatory hypertrophy.
目的
慢性轻度或中度创伤性脑损伤患者存在一些脑萎缩区域（包括脑白质），但更多区域存在脑异常增大（包括其他脑区）。
假设
同侧损伤和萎缩导致对侧代偿性肥大的最终发展。
材料与方法
将50例轻度或中度创伤性脑损伤患者与80例正常对照者（n = 80）进行脑MRI体积不对称性比较。基于不对称性的相关性用于检验主要假设。
结果
患者组存在多个异常不对称区域。
结论
相关性分析支持以下结论，即同侧脑白质区域的急性损伤导致萎缩，最终由于代偿性肥大导致对侧区域异常增大。
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