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单纯疱疹病毒2型感染中的埃尔斯伯格综合征。

Elsberg syndrome in HSV-2 infection.

作者信息

Belfaqeeh Omar, Markley Alexandria, Patel Mudita, Markoff Brian, Osorio Georgina

机构信息

Mount Sinai Morningside-West Hospital Center, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

出版信息

IDCases. 2023 Feb 16;31:e01714. doi: 10.1016/j.idcr.2023.e01714. eCollection 2023.

DOI:10.1016/j.idcr.2023.e01714
PMID:36875152
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9978459/
Abstract

Elsberg syndrome (ES) is a neuroinflammatory disease that causes acute or subacute lumbosacral radiculitis, with or without myelitis which accounts for approximately 5-10% of cauda equina syndrome and myelitis. We herein present a case of a middle-aged female who recently returned from the Dominican Republic and presented to the emergency room with complaints of a 10-day history of progressive lower extremity sensory changes and weakness preceded by transient bilateral arm pain and neck and head pressure. Based on clinical, radiographic, and serological testing the patient was diagnosed with HSV2 lumbosacral radiculitis (ES). After 21 days of Acyclovir, 5 days of high dose IV methylprednisolone, and one month of inpatient rehab, our patient was discharged home walking with a cane. As ES is poorly defined and rarely reported, it can be unrecognized in patients with acute cauda equina syndrome (CES). Appropriate testing for viral infection in a timely manner facilitates reaching a definitive diagnosis and prompt initiation of treatment, which is essential for resolution of symptoms.

摘要

埃尔斯伯格综合征(ES)是一种神经炎症性疾病,可导致急性或亚急性腰骶神经根炎,伴或不伴有脊髓炎,约占马尾综合征和脊髓炎的5%-10%。我们在此报告一例中年女性病例,该患者最近从多米尼加共和国返回,因下肢进行性感觉改变和无力10天就诊于急诊室,在此之前有短暂的双侧手臂疼痛以及颈部和头部压迫感。根据临床、影像学和血清学检查,该患者被诊断为单纯疱疹病毒2型腰骶神经根炎(ES)。经过21天的阿昔洛韦治疗、5天的大剂量静脉注射甲泼尼龙以及1个月的住院康复治疗后,我们的患者出院回家,需拄拐杖行走。由于ES的定义不明确且报道较少,在急性马尾综合征(CES)患者中可能未被识别。及时进行适当的病毒感染检测有助于明确诊断并迅速开始治疗,这对于症状的缓解至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b087/9978459/ad67766a3ce5/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b087/9978459/ad67766a3ce5/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b087/9978459/ad67766a3ce5/gr1.jpg

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J Investig Med High Impact Case Rep. 2022 Jan-Dec;10:23247096211063348. doi: 10.1177/23247096211063348.
2
A Case of Elsberg Syndrome in the Setting of Asymptomatic SARS-CoV-2 Infection.无症状 SARS-CoV-2 感染背景下的 Elsberg 综合征一例。
J Clin Neuromuscul Dis. 2021 Jun 1;22(4):228-231. doi: 10.1097/CND.0000000000000369.
3
Cauda equina syndrome due to herpes simplex virus type 2-associated meningoradiculitis (Elsberg syndrome) after posterior lumbar spinal fusion surgery: Case report and review of literature.
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Clin Neurol Neurosurg. 2021 Apr 1;205:106624. doi: 10.1016/j.clineuro.2021.106624.
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Clinical features of aseptic meningitis with varicella zoster virus infection diagnosed by next-generation sequencing: case reports.采用下一代测序诊断水痘带状疱疹病毒感染性无菌性脑膜炎的临床特征:病例报告。
BMC Infect Dis. 2020 Jun 22;20(1):435. doi: 10.1186/s12879-020-05155-8.
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Sacral Myeloradiculitis: An Uncommon Complication of Genital Herpes Infection.骶神经根炎:生殖器疱疹感染的一种罕见并发症。
Pediatrics. 2019 Jul;144(1). doi: 10.1542/peds.2018-2631.
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Elsberg syndrome related to varicella zoster virus infection with painless skin lesions in an elderly woman with poorly controlled type 2 diabetes mellitus.与水痘带状疱疹病毒感染相关的埃尔斯伯格综合征,在一名2型糖尿病控制不佳的老年女性中出现无痛性皮肤病变。
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