Cesur Ilknur Banlı, Özçelik Zerrin
Pediatric Surgery, Adana City Training Hospital, Adana, TUR.
Cureus. 2023 Mar 2;15(3):e35705. doi: 10.7759/cureus.35705. eCollection 2023 Mar.
Neuroblastomas (NB) are among the most frequent childhood solid tumors. The link between inflammation and cancer is well understood. Many research studies have been conducted to determine the prognostic importance of inflammatory markers in cancer patients. C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) are all potential inflammation indicators. The purpose of this study is to assess the efficacy of NLR and SII as inflammatory indicators in predicting NB patient survival.
Patients with NB diagnosed between January 1, 2012 and December 31, 2021 were studied retrospectively, and death was documented. By dividing the number of neutrophils by the number of lymphocytes, the NLR was obtained. The SII was calculated by multiplying the NLR by the platelet count.
46 patients with NB were included in the study with a mean age of 57.58 months (4.14-170.05). When the patients were analyzed based on mortality the NLR and SII values were statistically significantly increased in the dead group (2.71 (1.22-4.1 ) vs. 1.7 (0.16-5.1); p=0.02; and 677.8 (215-1322) vs. 294.6 (69.49-799.1), respectively; p=0.012). Analysis of the receiver operating curve found that 328.49 is the ideal cutoff value for SII to predict mortality with a sensitivity of 83% and a specificity of 68% (area under the receiver operating characteristic curve = 0.814 (95% confidence interval: 0.671-0.956), p=0.005 ). Analyzing the influence of risk factors on survival using Cox regression analysis, SII was discovered as a significant predictor of survival in the study (HR =1.001, 95% CI =1-1.20; p=0.049).
SII may be used to predict the overall survival of NB patients.
神经母细胞瘤（NB）是儿童期最常见的实体瘤之一。炎症与癌症之间的联系已为人熟知。已经开展了许多研究以确定炎症标志物在癌症患者中的预后重要性。C反应蛋白（CRP）、中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）以及全身免疫炎症指数（SII）都是潜在的炎症指标。本研究的目的是评估NLR和SII作为炎症指标在预测NB患者生存方面的有效性。
对2012年1月1日至2021年12月31日期间确诊的NB患者进行回顾性研究，并记录死亡情况。通过将中性粒细胞数量除以淋巴细胞数量得出NLR。SII通过将NLR乘以血小板计数来计算。
46例NB患者纳入研究，平均年龄57.58个月（4.14 - 170.05）。根据死亡率对患者进行分析时，死亡组的NLR和SII值在统计学上显著升高（分别为2.71（1.22 - 4.1）对1.7（0.16 - 5.1）；p = 0.02；以及677.8（215 - 1322）对294.6（69.49 - 799.1），p = 0.012）。对受试者工作曲线进行分析发现，328.49是SII预测死亡率的理想临界值，敏感性为83%，特异性为68%（受试者工作特征曲线下面积 = 0.814（95%置信区间：0.671 - 0.956），p = 0.005）。使用Cox回归分析危险因素对生存的影响时，发现SII是该研究中生存的显著预测因素（HR = 1.001，95% CI = 1 - 1.20；p = 0.049）。
SII可用于预测NB患者的总生存。
