The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Science, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing, China.
Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Front Endocrinol (Lausanne). 2023 Feb 16;14:1110337. doi: 10.3389/fendo.2023.1110337. eCollection 2023.
Diabetes mellitus (DM), a metabolic disease that has attracted significant research and clinical attention over the years, can affect the eye structure and induce cataract in patients diagnosed with DM. Recent studies have indicated the relationship between glycoprotein non-metastatic melanoma protein B (GPNMB) and DM and DM-related renal dysfunction. However, the role of circulating GPNMB in DM-associated cataract is still unknown. In this study, we explored the potential of serum GPNMB as a biomarker for DM and DM-associated cataract.
A total of 406 subjects were enrolled, including 60 and 346 subjects with and without DM, respectively. The presence of cataract was evaluated and serum GPNMB levels were measured using a commercial enzyme-linked immunosorbent assay kit.
Serum GPNMB levels were higher in diabetic individuals and subjects with cataract than in those without DM or cataract. Subjects in the highest GPNMB tertile group were more likely to have metabolic disorder, cataract, and DM. Analysis performed in subjects with DM elucidated the correlation between serum GPNMB levels and cataract. Receiver operating characteristic (ROC) curve analysis also indicated that GPNMB could be used to diagnose DM and cataract. Multivariable logistic regression analysis illustrated that GPNMB levels were independently associated with DM and cataract. DM was also found to be an independent risk factor for cataract. Further surveys revealed the combination of serum GPNMB levels and presence of DM was associated with a more precise identification of cataract than either factor alone.
Increased circulating GPNMB levels are associated with DM and cataract and can be used as a biomarker of DM-associated cataract.
糖尿病（DM）是一种代谢疾病，近年来引起了广泛的研究和临床关注，它可以影响眼睛结构并导致 DM 患者发生白内障。最近的研究表明糖蛋白非转移性黑色素瘤蛋白 B（GPNMB）与 DM 和 DM 相关的肾功能障碍之间存在关联。然而，循环 GPNMB 在 DM 相关白内障中的作用尚不清楚。在本研究中，我们探讨了血清 GPNMB 作为 DM 和 DM 相关白内障的潜在生物标志物的可能性。
共纳入 406 名受试者，其中 60 名和 346 名受试者分别患有 DM 和无 DM。使用商业酶联免疫吸附测定试剂盒评估白内障的存在并测量血清 GPNMB 水平。
糖尿病患者和白内障患者的血清 GPNMB 水平高于无 DM 或无白内障患者。血清 GPNMB 三分位组最高的受试者更可能患有代谢紊乱、白内障和 DM。在 DM 受试者中进行的分析阐明了血清 GPNMB 水平与白内障之间的相关性。受试者工作特征（ROC）曲线分析也表明 GPNMB 可用于诊断 DM 和白内障。多变量逻辑回归分析表明 GPNMB 水平与 DM 和白内障独立相关。DM 也是白内障的独立危险因素。进一步的调查表明，血清 GPNMB 水平与 DM 的组合与单独使用任一因素相比，更能准确识别白内障。
循环 GPNMB 水平升高与 DM 和白内障有关，可作为 DM 相关白内障的生物标志物。
