Park Sang-Min, Lee Seung Hyun, Zhao HuiYan, Kim Jeongtae, Jang Jae Young, Choi Yujin, Jeong Soyeon, Son Soyeong, Jung Kyungsook, Jang Jung-Hee
College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea.
Interdisciplinary Program in Precision Public Health, Korea University, Seoul, Republic of Korea.
Front Neurosci. 2023 Feb 16;17:1108371. doi: 10.3389/fnins.2023.1108371. eCollection 2023.
Alzheimer's disease (AD) is a chronic progressive neurodegenerative disease characterized by the deposition of amyloid-beta (Aβ) peptide and neurofibrillary tangles in the brain. The approved drug for AD has certain limitations such as a short period of cognitive improvement effect; moreover, the development of drug for AD therapeutic single target for Aβ clearance in brain ended in failure. Therefore, diagnosis and treatment of AD using a multi-target strategy according to the modulation of the peripheral system, which is not only limited to the brain, is needed. Traditional herbal medicines can be beneficial for AD based on a holistic theory and personalized treatment according to the time-order progression of AD. This literature review aimed to investigate the effectiveness of herbal medicine therapy based on syndrome differentiation, a unique theory of traditional diagnosis based on the holistic system, for multi-target and multi-time treatment of mild cognitive impairment or AD stage. Possible interdisciplinary biomarkers including transcriptomic and neuroimaging studies by herbal medicine therapy for AD were investigated. In addition, the mechanism by which herbal medicines affect the central nervous system in connection with the peripheral system in an animal model of cognitive impairment was reviewed. Herbal medicine may be a promising therapy for the prevention and treatment of AD through a multi-target and multi-time strategy. This review would contribute to the development of interdisciplinary biomarkers and understanding of the mechanisms of action of herbal medicine in AD.
阿尔茨海默病（AD）是一种慢性进行性神经退行性疾病，其特征是大脑中存在β-淀粉样蛋白（Aβ）肽沉积和神经原纤维缠结。已获批用于治疗AD的药物存在一定局限性，如认知改善效果持续时间短；此外，针对大脑中Aβ清除的AD治疗单靶点药物研发也以失败告终。因此，需要采用一种不仅局限于大脑，而是根据外周系统调节的多靶点策略来诊断和治疗AD。传统草药基于整体理论以及根据AD的时序进展进行个性化治疗，可能对AD有益。这篇文献综述旨在研究基于辨证论治（一种基于整体系统的独特传统诊断理论）的草药疗法对轻度认知障碍或AD阶段进行多靶点、多时段治疗的有效性。研究了草药疗法治疗AD可能的跨学科生物标志物，包括转录组学和神经影像学研究。此外，还综述了在认知障碍动物模型中，草药通过外周系统影响中枢神经系统的机制。草药可能是一种通过多靶点、多时段策略预防和治疗AD的有前景的疗法。这篇综述将有助于跨学科生物标志物的开发以及对草药在AD中作用机制的理解。
