Spillert C R, Cooper D M, Lazaro E J
Department of Surgery, UMD-New Jersey Medical School, Newark, New Jersey 07103-2757.
Agents Actions. 1987 Aug;21(3-4):260-1. doi: 10.1007/BF01966484.
We have shown that the drug combination of sulfamethoxazole and trimethoprim has a radio protective effect in mice. Since radiation injury is due in part to microvascular thrombosis produced by the release or action of thromboplastin, we evaluated the effect of these drugs individually on thromboplastin-accelerated coagulation. Sulfamethoxazole at a final concentration of 0.05 microgram/ml and trimethoprim at concentrations of 0.005 and 0.05 microgram/ml significantly prolonged the recalcification times of human plasma. Whether these drugs have an anticoagulant effect when employed clinically remains to be determined.
我们已经表明，磺胺甲恶唑和甲氧苄啶的药物组合对小鼠具有辐射防护作用。由于辐射损伤部分归因于凝血活酶释放或作用所产生的微血管血栓形成，我们分别评估了这些药物对凝血活酶加速凝血的影响。终浓度为0.05微克/毫升的磺胺甲恶唑以及浓度为0.005和0.05微克/毫升的甲氧苄啶显著延长了人血浆的再钙化时间。这些药物在临床应用时是否具有抗凝作用仍有待确定。
