Indiveri M C, Hirsh D C
J Am Vet Med Assoc. 1986 Jan 1;188(1):46-8.
Susceptibilities of trimethoprim and sulfamethoxazole were tested alone and in combination (1:20) against 94 isolants of obligate anaerobes from clinical specimens. Ninety percent of the isolants were inhibited by less than 0.25 microgram - less than 4.75 micrograms trimethoprim-sulfamethoxazole/ml; 5.4 micrograms trimethoprim/ml and; 900 micrograms sulfamethoxazole/ml. We concluded that trimethoprim-sulfamethoxazole would be effective in the treatment of infectious processes containing species of obligate anaerobes, including those resistant to the penicillin and cephalothin groups of antibiotics.
对来自临床标本的94株专性厌氧菌分离株分别单独及联合（1:20）检测了甲氧苄啶和磺胺甲恶唑的敏感性。90%的分离株被低于0.25微克 - 低于4.75微克甲氧苄啶-磺胺甲恶唑/毫升、5.4微克甲氧苄啶/毫升和900微克磺胺甲恶唑/毫升所抑制。我们得出结论，甲氧苄啶-磺胺甲恶唑对包含专性厌氧菌的感染性疾病有效，包括那些对青霉素类和头孢菌素类抗生素耐药的疾病。
