Haykal Siba, Barone Natasha, Rostami Sara, Moshkelgosha Sajad, Juvet Stephen, Keshavjee Shaf, Ghazarian Danny
Latner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, Department of Surgery, University Health Network, University of Toronto, Toronto, ON, Canada.
Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Plast Reconstr Surg Glob Open. 2023 Mar 3;11(3):e4831. doi: 10.1097/GOX.0000000000004831. eCollection 2023 Mar.
Acute rejection in vascularized composite allotransplantation has been identified using the Banff 2007 working classification. We propose an addition to this classification based on histological and immunological assessment within the skin and subcutaneous tissue.
Biopsies from vascularized composite transplant patients were obtained at scheduled visits and whenever skin changes occurred. Histology and immunohistochemistry were performed on all samples, looking at infiltrating cells.
Observations were made specifically related to each component of the skin, including the epidermis, dermis, vessels, and subcutaneous tissue. Our findings led to the establishment of the University Health Network addition of skin rejection.
The high rate of rejection where the skin is involved requires novel techniques for early detection. The University Health Network skin rejection addition can serve as an adjunct to the Banff classification.
已使用2007年班夫工作分类法识别血管化复合组织移植中的急性排斥反应。我们基于皮肤和皮下组织内的组织学和免疫学评估，提议对该分类法进行补充。
在血管化复合移植患者的定期随访以及皮肤出现变化时进行活检。对所有样本进行组织学和免疫组织化学检查，观察浸润细胞。
针对皮肤的每个组成部分进行了具体观察，包括表皮、真皮、血管和皮下组织。我们的研究结果促成了大学健康网络皮肤排斥反应补充分类法的建立。
涉及皮肤的排斥反应发生率很高，需要新的早期检测技术。大学健康网络皮肤排斥反应补充分类法可作为班夫分类法的辅助方法。
