Smith Amy E, Kane Alisa, Watts Francesca, Qiu Min, Chin Venessa
The Kinghorn Cancer Centre, St Vincent's Hospital, Sydney, NSW, Australia.
School of Medicine, University of Notre Dame Australia, Sydney, NSW, Australia.
Case Rep Oncol. 2023 Feb 28;16(1):116-123. doi: 10.1159/000529425. eCollection 2023 Jan-Dec.
Thymic tumours are rare thoracic malignancies with thymic carcinoma accounting for approximately 12% of all thymic tumours compared to thymomas which account for approximately 86%. Unlike thymomas, it is very rare for thymic carcinomas to be associated with autoimmune disorders or paraneoplastic syndromes. When these phenomena do occur, the vast majority are myasthenia gravis, pure red cell aplasia, or systemic lupus erythematous. Paraneoplastic Sjogren's syndrome is a rare complication of thymic carcinoma, with only two cases previously reported. Here we present 2 cases of patients with metastatic thymic carcinoma who developed autoimmune phenomena consistent with Sjogren's syndrome without classical symptoms prior to treatment. One patient opted for surveillance of their malignancy, while the other underwent chemoimmunotherapy with favourable results. These case reports describe two distinctive clinical presentations of a rare paraneoplastic phenomenon.
胸腺瘤是罕见的胸部恶性肿瘤，胸腺癌约占所有胸腺瘤的12%，而胸腺瘤约占86%。与胸腺瘤不同，胸腺癌很少与自身免疫性疾病或副肿瘤综合征相关。当这些现象确实发生时，绝大多数是重症肌无力、纯红细胞再生障碍或系统性红斑狼疮。副肿瘤性干燥综合征是胸腺癌的一种罕见并发症，此前仅报道过两例。在此，我们报告2例转移性胸腺癌患者，他们在治疗前出现了与干燥综合征相符的自身免疫现象，但无典型症状。一名患者选择对其恶性肿瘤进行监测，而另一名患者接受了化学免疫治疗，效果良好。这些病例报告描述了一种罕见的副肿瘤现象的两种独特临床表现。
