• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

肝射频热消融术后转移性肝细胞癌的快速播散与自发消退：一例相关免疫分析的病例报告

Rapid Dissemination followed by Spontaneous Regression of Metastatic Hepatocellular Carcinoma after Liver Radiofrequency Thermal Ablation: A Case Report with Correlative Immune Assay.

作者信息

Xu Yiqing, Bayewitz Ashrei, Tary-Lehmann Magdalena

机构信息

Division of Hematology/Oncology, Department of Medicine, Maimonides Medical Center, Brooklyn, NY, USA.

Division of Hematology/Oncology, Department of Medicine, Coney Island Hospital, Brooklyn, NY, USA.

出版信息

Case Rep Oncol. 2023 Mar 1;16(1):129-136. doi: 10.1159/000527229. eCollection 2023 Jan-Dec.

DOI:10.1159/000527229
PMID:36876217
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9978950/
Abstract

Rapid intrahepatic and distant metastasis of hepatocellular carcinoma (HCC) after locoregional treatment for early stage tumor is very rare. Descriptions of spontaneous regression of HCC exist in case reports, but its true mechanism is unclear. Here, we describe a case of rapid dissemination with lung metastasis shortly after localized RFA treatment of HCC liver lesions, followed by spontaneous, sustained regression of those lung lesions. We also show the detection of cytotoxic T lymphocytes (CTLs) specific to hepatitis B antigens by immune assay in this patient. We propose immune-related destruction as the basis for spontaneous regression.

摘要

早期肿瘤经局部区域治疗后，肝细胞癌（HCC）发生快速肝内及远处转移的情况极为罕见。HCC自发消退的病例报告虽有记载，但其确切机制尚不清楚。在此，我们描述了1例HCC肝脏病灶经局部射频消融（RFA）治疗后不久即出现快速播散并伴有肺转移，随后这些肺部病灶又自发持续消退的病例。我们还通过免疫分析检测到该患者体内存在针对乙型肝炎抗原的细胞毒性T淋巴细胞（CTL）。我们提出免疫相关破坏是自发消退的基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da7/9978950/0bb039a98fde/cro-2023-0016-0001-527229_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da7/9978950/0bb039a98fde/cro-2023-0016-0001-527229_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1da7/9978950/0bb039a98fde/cro-2023-0016-0001-527229_F1.jpg

相似文献

1
Rapid Dissemination followed by Spontaneous Regression of Metastatic Hepatocellular Carcinoma after Liver Radiofrequency Thermal Ablation: A Case Report with Correlative Immune Assay.肝射频热消融术后转移性肝细胞癌的快速播散与自发消退：一例相关免疫分析的病例报告
Case Rep Oncol. 2023 Mar 1;16(1):129-136. doi: 10.1159/000527229. eCollection 2023 Jan-Dec.
2
Radiofrequency ablation for hepatocellular carcinoma induces glypican-3 peptide-specific cytotoxic T lymphocytes.射频消融治疗肝细胞癌诱导磷脂酰聚糖 3 肽特异性细胞毒性 T 淋巴细胞。
Int J Oncol. 2012 Jan;40(1):63-70. doi: 10.3892/ijo.2011.1202. Epub 2011 Sep 15.
3
Radiofrequency thermal ablation of hepatocellular carcinoma liver nodules can activate and enhance tumor-specific T-cell responses.肝细胞癌肝结节的射频热消融可激活并增强肿瘤特异性T细胞反应。
Cancer Res. 2006 Jan 15;66(2):1139-46. doi: 10.1158/0008-5472.CAN-05-2244.
4
Noninvasive fibrosis indices predict intrahepatic distant recurrence of hepatitis B-related hepatocellular carcinoma following radiofrequency ablation.非侵入性纤维化指标预测乙型肝炎相关肝细胞癌射频消融术后肝内远处复发。
Liver Int. 2013 Jul;33(6):884-93. doi: 10.1111/liv.12132. Epub 2013 Mar 5.
5
Platelet lysates in Hepatocellular Carcinoma patients after radiofrequency ablation facilitate tumor proliferation, invasion and vasculogenic mimicry.射频消融术后肝癌患者血小板裂解物促进肿瘤增殖、侵袭和血管生成拟态。
Int J Med Sci. 2020 Jul 29;17(14):2104-2112. doi: 10.7150/ijms.44405. eCollection 2020.
6
Effectiveness and safety in radiofrequency ablation of pulmonary metastases from HCC: a five years study.射频消融治疗 HCC 肺转移瘤的有效性和安全性：一项五年研究。
Med Oncol. 2020 Mar 12;37(4):25. doi: 10.1007/s12032-020-01352-2.
7
Outcomes of radiofrequency ablation as first-line therapy for hepatocellular carcinoma less than 3 cm in potentially transplantable patients.射频消融作为潜在可移植患者小于 3cm 的肝细胞癌一线治疗的结果。
J Hepatol. 2019 May;70(5):866-873. doi: 10.1016/j.jhep.2018.12.027. Epub 2019 Jan 5.
8
[Clinical application of ultrasound-guided radiofrequency ablation for primary hepatocellular carcinoma near the liver surface].超声引导下射频消融治疗肝表面原发性肝癌的临床应用
Zhonghua Zhong Liu Za Zhi. 2015 Dec;37(12):933-7.
9
A case of rapid intrahepatic dissemination of hepatocellular carcinoma after radiofrequency thermal ablation.1例肝细胞癌射频热消融术后肝内快速播散病例
Am J Surg. 2004 Aug;188(2):165-7. doi: 10.1016/j.amjsurg.2003.12.061.
10
Enhancement of tumor-associated antigen-specific T cell responses by radiofrequency ablation of hepatocellular carcinoma.射频消融肝癌增强肿瘤相关抗原特异性 T 细胞反应。
Hepatology. 2013 Apr;57(4):1448-57. doi: 10.1002/hep.26153.

本文引用的文献

1
The Immune Modulation Effect of Locoregional Therapies and Its Potential Synergy with Immunotherapy in Hepatocellular Carcinoma.局部区域治疗在肝细胞癌中的免疫调节作用及其与免疫治疗的潜在协同作用
J Hepatocell Carcinoma. 2020 Feb 10;7:11-17. doi: 10.2147/JHC.S187121. eCollection 2020.
2
Immune checkpoint inhibitors in the treatment of virus-associated cancers.免疫检查点抑制剂在病毒相关性癌症治疗中的应用。
J Hematol Oncol. 2019 Jun 10;12(1):58. doi: 10.1186/s13045-019-0743-4.
3
Combining immunotherapy and radiotherapy in lung cancer.肺癌中免疫疗法与放射疗法的联合应用。
J Thorac Dis. 2018 May;10(Suppl 13):S1447-S1460. doi: 10.21037/jtd.2018.05.107.
4
Percutaneous treatment of hepatocellular carcinoma: State of the art and innovations.经皮治疗肝细胞癌：现状与创新。
J Hepatol. 2018 Apr;68(4):783-797. doi: 10.1016/j.jhep.2017.10.004. Epub 2017 Oct 13.
5
Spontaneous regression of hepatocellular carcinoma: A mini-review.肝细胞癌的自发消退：一篇综述。
World J Gastroenterol. 2017 Jun 7;23(21):3797-3804. doi: 10.3748/wjg.v23.i21.3797.
6
Unresectable Hepatocellular Carcinoma: Radioembolization Versus Chemoembolization: A Systematic Review and Meta-analysis.不可切除肝细胞癌：放射性栓塞与化疗栓塞：系统评价与荟萃分析
Cardiovasc Intervent Radiol. 2016 Nov;39(11):1580-1588. doi: 10.1007/s00270-016-1426-y. Epub 2016 Sep 1.
7
Hepatocellular Carcinoma From Epidemiology to Prevention: Translating Knowledge into Practice.肝细胞癌：从流行病学到预防——将知识转化为实践
Clin Gastroenterol Hepatol. 2015 Nov;13(12):2140-51. doi: 10.1016/j.cgh.2015.08.014. Epub 2015 Aug 15.
8
Role of Local Radiation Therapy in Cancer Immunotherapy.局部放疗在癌症免疫治疗中的作用。
JAMA Oncol. 2015 Dec;1(9):1325-32. doi: 10.1001/jamaoncol.2015.2756.
9
Immune Response in Hepatitis B Virus Infection.乙型肝炎病毒感染中的免疫反应
Cold Spring Harb Perspect Med. 2015 Jul 1;5(8):a021428. doi: 10.1101/cshperspect.a021428.
10
Cases of spontaneous tumor regression in hepatobiliary cancers: implications for immunotherapy?肝胆癌自发肿瘤消退病例：对免疫治疗有何启示？
J Gastrointest Cancer. 2015 Jun;46(2):161-5. doi: 10.1007/s12029-015-9690-7.