Bratisl Lek Listy. 2023;124(5):368-372. doi: 10.4149/BLL_2023_056.
Purpose of this study was to evaluate properties of apelin, a peptide detectable in peripheral blood, for atrial fibrillation (AF) detection in a diverse population of patients covering a broad spectrum from healthy to polymorbid patients.
AF is the most common cardiac arrhythmia with constantly increasing incidence and prevalence. Currently available diagnostic tools do not provide sufficient detection rate. Large proportion of patients with AF remains undiagnosed and the possibility of screening at-risk groups would be significantly beneficial.
We designed this study as a multi-centre retrospective study. Study population included 183 patients. 64 in non-AF and 119 in AF group.
Apelin plasma concentration was significantly lower in AF group compared to non-AF group (p < 0.001). Receiver operating characteristic analysis of apelin as a predictor of AF scored area under the curve of 0.79, sensitivity = 0.941 and specificity = 0.578. Multivariate analysis using logistic regression adjusted for age, BMI, apelin, dilated LV, dilated LA, arterial hypertension, and gender showed only apelin and age to be statistically significant contributors for AF.
Apelin might be a promising biomarker for detecting AF in our study population. These results suggest promising potential of apelin as a screening biomarker for AF (Tab. 2, Fig. 1, Ref. 46). Text in PDF www.elis.sk Keywords: biomarker, apelin, arrhythmia, atrial fibrillation.
本研究旨在评估在外周血中可检测到的肽类物——apelin，用于检测来自健康至多病患者的广泛人群中的房颤（AF）。
AF 是最常见的心律失常，发病率和患病率不断上升。目前可用的诊断工具不能提供足够的检出率。大量 AF 患者未被诊断，对高危人群进行筛查的可能性将具有显著益处。
我们将这项研究设计为一项多中心回顾性研究。研究人群包括 183 名患者。64 名在非 AF 组，119 名在 AF 组。
与非 AF 组相比，AF 组的 apelin 血浆浓度明显降低（p < 0.001）。apelin 作为 AF 预测因子的受试者工作特征分析的曲线下面积为 0.79，敏感性为 0.941，特异性为 0.578。使用逻辑回归进行多变量分析，调整年龄、BMI、apelin、扩张的 LV、扩张的 LA、动脉高血压和性别，只有 apelin 和年龄是 AF 的统计学显著贡献因素。
apelin 可能是我们研究人群中检测 AF 的有前途的生物标志物。这些结果表明，apelin 作为 AF 的筛查生物标志物具有很大的潜力（表 2，图 1，参考文献 46）。
