Braend M, Aursjø J, Austbø O
Acta Vet Scand. 1987;28(1):121-3. doi: 10.1186/BF03548263.
Thirty years have passed since it was shown that sheep have two types of haemoglobin (Hb), A and B. Since then a large number of studies have been undertaken; gene frequencies, relations and origins of breeds, biochemistry, correlations with diseases, to mention the most important fields for which these 2 haemoglobins have been utilized. A few years ago, in a number of studies, Vestri and coworkers ( 1983) using chromatographic and biochemical methods together with isoelectric focusing showed that in Italian sheep additional Hb types occurred. These new types are caused by substitutions in the alpha chains, in contrast to the A and B difference which is caused by 7 amino acid substitutions in the beta chain ( 1965). (1983) also proved that the alpha chains in sheep, as in man, horse and goat among others, are controlled by 2 closely linked alpha globin genes.
自发现绵羊有两种血红蛋白（Hb），即A和B以来，已经过去了三十年。从那时起，人们进行了大量研究；基因频率、品种的关系和起源、生物化学、与疾病的相关性，这些都是利用这两种血红蛋白的最重要领域。几年前，在一些研究中，韦斯特里及其同事（1983年）使用色谱和生化方法以及等电聚焦表明，意大利绵羊中出现了额外的血红蛋白类型。与由β链上7个氨基酸取代引起的A和B差异不同，这些新类型是由α链上的取代引起的（1965年）。（1983年）还证明，绵羊的α链，与人、马和山羊等动物一样，由两个紧密连锁的α珠蛋白基因控制。
