Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.
Eur Rev Med Pharmacol Sci. 2023 Feb;27(4):1582-1591. doi: 10.26355/eurrev_202302_31401.
Non-thyroidal-illness syndrome (NTIS) refers to condition found in chronic diseases that is an adaptive mechanism. However, oxidative stress is related to NTIS in a vicious circle, due to deiodinases alteration and negative effects of low T3 on antioxidant levels or activity. Muscle is one of the main targets of thyroid hormones and it can secrete a myokine named irisin, which is able to induce the browning of white adipose tissue, energy expenditure and protect against insulin resistance. Inconclusive data have been reported about irisin role in chronic diseases. Moreover, no correlation with antioxidants has been investigated. Therefore, we performed a case-control study with the primary endpoint to evaluate irisin levels in two models of NTIS, such as chronic heart failure (CHF) and chronic kidney disease (CKD) during haemodialytic treatment. The secondary endpoint was the correlation with total antioxidant capacity (TAC) to establish a possible role of irisin in the modulation of antioxidant systems.
Three groups of subjects were enrolled. Group A included CHF patients (n=18; aged 70.22 ± 2.78 ys; BMI ± 27.75 ± 1.28 kg/m2); Group B included CKD patients (n=29; aged 67.03 ± 2.64; BMI 24.53 ± 1.01); finally, 11 normal subjects (Group C) have been enrolled as controls. Irisin has been evaluated by ELISA method and Total Antioxidant Capacity (TAC) by spectrophotometric method.
Irisin was significantly higher in Group B vs. A and C groups (Mean ± SEM: 20.18 ± 0.61 ng/ml vs. 2.77 ± 0.77 and 13.06 ± 0.56, respectively; p<0.05); a significant correlation between irisin and TAC was observed in group B.
These preliminary data suggest a possible role of irisin in the modulation of antioxidants in two chronic syndromes with low T3 (i.e., CHF and CKD) with differential pattern in these two models studied. Further insights are needed to confirm this pilot study, which could be the basis for a longitudinal investigation, to assess a prognostic role of irisin with possible therapeutic implications.
非甲状腺疾病综合征（NTIS）是指慢性疾病中发现的一种适应机制。然而，氧化应激与 NTIS 之间存在恶性循环，这是由于脱碘酶的改变以及低 T3 对抗氧化水平或活性的负面影响。肌肉是甲状腺激素的主要靶标之一，它可以分泌一种名为鸢尾素的肌因子，能够诱导白色脂肪组织的褐色化、能量消耗和抵抗胰岛素抵抗。关于鸢尾素在慢性疾病中的作用，已有报道结果不一。此外，尚未研究其与抗氧化剂的相关性。因此，我们进行了一项病例对照研究，主要终点是评估两种 NTIS 模型（即慢性心力衰竭（CHF）和慢性肾脏病（CKD）在血液透析治疗期间鸢尾素水平。次要终点是与总抗氧化能力（TAC）的相关性，以确定鸢尾素在调节抗氧化系统中的可能作用。
纳入了三组受试者。A 组包括 CHF 患者（n=18；年龄 70.22±2.78 岁；BMI±27.75±1.28kg/m2）；B 组包括 CKD 患者（n=29；年龄 67.03±2.64；BMI 24.53±1.01）；最后，纳入了 11 名正常受试者（C 组）作为对照组。采用 ELISA 法检测鸢尾素，分光光度法检测总抗氧化能力（TAC）。
B 组鸢尾素明显高于 A 组和 C 组（均值±SEM：20.18±0.61ng/ml 比 2.77±0.77 和 13.06±0.56，分别；p<0.05）；B 组观察到鸢尾素与 TAC 之间存在显著相关性。
这些初步数据表明，鸢尾素在两种低 T3 的慢性综合征（即 CHF 和 CKD）的抗氧化剂调节中可能发挥作用，在这两种研究模型中存在不同的模式。需要进一步的研究来证实这项初步研究，这可能是进行纵向研究的基础，以评估鸢尾素的预后作用及其可能的治疗意义。
