Department of Chemistry, College of Science, Al-Nahrain University, Baghdad, Iraq.
Asian Pac J Cancer Prev. 2022 Aug 1;23(8):2649-2654. doi: 10.31557/APJCP.2022.23.8.2649.
Gastric and colorectal cancers are two obesity-related cancers. Irisin is a dipo-myokine with an important role in the body's energy homeostasis. Oxidative Stress has a crucial role in tumorigenesis. Therefore, this study aims to investigate the association of circulating irisin with oxidative stress in gastric and colorectal cancer patients.
A case-control study involving 62 gastric and colorectal cancers and 22 healthy individuals was carried out. Serum irisin and Total Antioxidant Capacity were measured by sandwich enzyme-linked immunosorbed assay (ELIZA) kits. Total Oxidative Stress (TOS) was measured using colorimetric methods and oxidative stress index (OSI) was also calculated.
Serum irisin decreased significantly (p<0.0001) in gastric and colorectal cancer cases compared to healthy individuals. The TOS and OSI levels increased significantly (p<0.0001) in gastric and colorectal cancer cases compared to healthy individuals. No significant correlation was found in terms of irisin, TOS, TAC, and OSI in gastric and colorectal cancer cases and control groups.
Circulating irisin decreases and oxidative stress increases in gastric and colorectal cancers. There is no correlation between irisin and oxidative stress. The mechanism by which irisin is associated with oxidative stress is still not clear.
胃癌和结直肠癌是两种与肥胖相关的癌症。鸢尾素是一种具有重要作用的脂肪-肌因子，参与机体能量稳态的调节。氧化应激在肿瘤发生中起着至关重要的作用。因此，本研究旨在探讨循环鸢尾素与胃癌和结直肠癌患者氧化应激之间的关系。
进行了一项病例对照研究，纳入了 62 例胃癌和结直肠癌患者和 22 例健康个体。采用夹心酶联免疫吸附测定（ELISA）试剂盒检测血清鸢尾素和总抗氧化能力。采用比色法测定总氧化应激（TOS），并计算氧化应激指数（OSI）。
与健康个体相比，胃癌和结直肠癌患者的血清鸢尾素水平显著降低（p<0.0001）。与健康个体相比，胃癌和结直肠癌患者的 TOS 和 OSI 水平显著升高（p<0.0001）。在胃癌和结直肠癌患者和对照组中，鸢尾素、TOS、TAC 和 OSI 之间均无显著相关性。
胃癌和结直肠癌患者的循环鸢尾素水平降低，氧化应激增加。鸢尾素与氧化应激之间无相关性。鸢尾素与氧化应激相关的机制尚不清楚。
