Woods H F, Weston M J, Bunting S
Proc Eur Dial Transplant Assoc. 1978;15:122-9.
Despite the use of heparin, activation of platelets on the artificial surface of dialyser membranes results in thrombus formation, microembolisation and thrombocytopenia. To assess the effects on these events of prostacyclin, three groups of healthy greyhounds were dialysed with heparin, heparin plus prostacyclin or prostacyclin alone. The use of prostacyclin, either alone or with heparin, abolished microembolisation from the dialyser and prevented thrombbocytopenia. With prostacyclin dialysis could be carried out without heparin and there was no clotting of blood within the extracorporeal circuit nor any change in tests of haemostasis.
尽管使用了肝素，但透析器膜人工表面上的血小板活化仍会导致血栓形成、微栓塞和血小板减少。为了评估前列环素对这些事件的影响，将三组健康的灵缇犬分别用肝素、肝素加前列环素或单独使用前列环素进行透析。单独使用前列环素或与肝素联合使用，均可消除透析器的微栓塞并预防血小板减少。使用前列环素时可在不使用肝素的情况下进行透析，体外循环内血液无凝血现象，止血试验也无任何变化。
