Rylance P B, Gordge M P, Ireland H, Lane D A, Weston M J
Proc Eur Dial Transplant Assoc Eur Ren Assoc. 1985;21:281-6.
Dialysis with prostacyclin (Epoprostenol, PGI2) alone prevents platelet activation and endothelial cell stimulation but not the elevation of fibrinopeptide A (FPA), a sensitive marker of fibrin generation. The generation of FPA may explain why some patients develop clot in the dialysis circuit during PGI2-only dialysis. In combination with heparin, PGI2 augments the anticoagulant effect of the heparin as well as providing platelet protection.
单独使用前列环素（依前列醇，PGI2）进行透析可防止血小板活化和内皮细胞刺激，但不能阻止纤维蛋白肽A（FPA，纤维蛋白生成的敏感标志物）升高。FPA的生成可能解释了为什么一些患者在仅使用PGI2透析期间透析回路中会形成血栓。与肝素联合使用时，PGI2可增强肝素的抗凝作用并提供血小板保护。
