State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Immaculate High School, Danbury, CT 06810, USA.
J Asian Nat Prod Res. 2024 Feb;26(2):280-292. doi: 10.1080/10286020.2023.2184356. Epub 2023 Mar 6.
Seven new pentasaccharides (-), rehmaglupentasaccharides A-G, were isolated from the air-dried roots of . Their structures were established from the spectroscopic data obtained and by chemical evidence. The known verbascose () and stachyose () were also obtained in the current investigation, and the structure of stachyose was unequivocally defined using X-ray diffraction data. Compounds - were tested for their cytotoxicity against five human tumor cell lines, influence on dopamine receptor activation, and proliferation effects against .
从 的干燥根部分离得到了七个新的五糖 (-)，即瑞马糖五糖 A-G。它们的结构是根据获得的光谱数据和化学证据确定的。在本次研究中还得到了已知的毛蕊花糖苷（）和水苏糖（），并使用 X 射线衍射数据明确确定了水苏糖的结构。测试了化合物 - 对五种人肿瘤细胞系的细胞毒性、对多巴胺受体激活的影响以及对 的增殖作用。
