怀地黄中的保肝环烯醚萜苷。
Hepatoprotective iridoid glycosides from the roots of Rehmannia glutinosa.
机构信息
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
出版信息
J Nat Prod. 2012 Sep 28;75(9):1625-31. doi: 10.1021/np300509z. Epub 2012 Aug 23.
Eleven new iridoid glycosides, rehmaglutosides A-K (1-11), together with 20 known analogues were isolated from the air-dried roots of Rehmannia glutinosa. The structures of these compounds were elucidated on the basis of spectroscopic data analysis and chemical evidence. Furthermore, in in vitro assays, compounds 3, 7, and 9-11 (10 μM) exhibited moderate hepatoprotective activities against D-galactosamine-induced HL-7702 cell damage.
从地黄的干燥根部分离得到了 11 个新的裂环环烯醚萜糖苷，即雷马苷 A-K（1-11），以及 20 个已知类似物。这些化合物的结构是基于光谱数据分析和化学证据来阐明的。此外，在体外实验中，化合物 3、7 和 9-11（10 μM）对 D-半乳糖胺诱导的 HL-7702 细胞损伤表现出中等的肝保护活性。
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