Eye Clinic, Department of Biomedical and Clinical Science, Luigi Sacco Hospital, University of Milan, Milan, Italy.
Eye Institute, Cleveland Clinic Abu Dhabi, Al Maryah Island, Abu Dhabi, United Arab Emirates.
Invest Ophthalmol Vis Sci. 2023 Mar 1;64(3):13. doi: 10.1167/iovs.64.3.13.
To assess retinal vein and artery diameters during active and inactive intraocular inflammation in eyes with uveitis.
Color fundus photographs and clinical data of eyes with uveitis collected during two visits (active disease [i.e., T0] and inactive stage [i.e., T1]) were reviewed. The images were semi-automatically analyzed to obtain the central retina vein equivalent (CRVE) and central retina artery equivalent (CRAE). Changes of CRVE and CRAE from T0 to T1 were calculated, and their possible correlation with clinical data, including age, gender, ethnicity, uveitis etiology, and visual acuity, were investigated.
Eighty-nine eyes were enrolled in the study. Both CRVE and CRAE reduced from T0 to T1 (P < 0.0001 and P = 0.01, respectively), with active inflammation being able to influence the CRVE and CRAE (P < 0.0001 and P = 0.0004, respectively) after accounting for all other variables. The degree of venular (∆V) and arteriolar (∆A) dilation was influenced only by time (P = 0.03 and P = 0.04, respectively). Best-corrected visual acuity was influenced by time and ethnicity (P = 0.003 and P = 0.0006).
CRVE and CRAE are increased in eyes with active intraocular inflammation regardless of the type of uveitis, and they decrease when the inflammation wears off.
评估葡萄膜炎患者活动期和非活动期眼内炎症时视网膜动静脉直径。
回顾性分析两次就诊（活动期[即 T0]和非活动期[即 T1]）的葡萄膜炎患者的眼底彩照和临床资料。对图像进行半自动分析，获得中心视网膜静脉等效直径（CRVE）和中心视网膜动脉等效直径（CRAE）。计算从 T0 到 T1 的 CRVE 和 CRAE 变化，并探讨其与包括年龄、性别、种族、葡萄膜炎病因和视力在内的临床数据的可能相关性。
本研究共纳入 89 只眼。从 T0 到 T1，CRVE 和 CRAE 均降低（P < 0.0001 和 P = 0.01），在考虑所有其他变量后，活动性炎症仍能影响 CRVE 和 CRAE（P < 0.0001 和 P = 0.0004）。静脉（∆V）和小动脉（∆A）扩张程度仅受时间影响（P = 0.03 和 P = 0.04）。最佳矫正视力受时间和种族影响（P = 0.003 和 P = 0.0006）。
无论葡萄膜炎类型如何，活动期眼内炎症患者的 CRVE 和 CRAE 增加，炎症消退后则降低。
