Li Qingmei, Mei Aihua, Qian Hang, Min Xinwen, Yang Handong, Zhong Jixin, Li Chunlei, Xu Hao, Chen Jun
Sinopharm Dongfeng General Hospital (Hubei Clinical Research Center of Hypertension), Hubei University of Medicine, Hubei Key Laboratory of Wudang Local Chinese Medicine Research (Hubei University of Medicine), Shiyan, China.
Department of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China.
Int Immunopharmacol. 2023 Apr;117:109955. doi: 10.1016/j.intimp.2023.109955. Epub 2023 Mar 4.
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population found in the bone marrow, peripheral blood, and tumor tissue. Their role is mainly to inhibit the monitoring function of innate and adaptive immune cells, which leads to the escape of tumor cells and promotes tumor development and metastasis. Moreover, recent studies have found that MDSCs are therapeutic in several autoimmune disorders due to their strong immunosuppressive ability. Additionally, studies have found that MDSCs have an important role in the formation and progression of other cardiovascular diseases, such as atherosclerosis, acute coronary syndrome, and hypertension. In this review, we will discuss the role of MDSCs in the pathogenesis and treatment of cardiovascular disease.
髓源性抑制细胞（MDSCs）是一种存在于骨髓、外周血和肿瘤组织中的异质性细胞群体。它们的主要作用是抑制固有免疫细胞和适应性免疫细胞的监测功能，这会导致肿瘤细胞逃逸并促进肿瘤发展和转移。此外，最近的研究发现，由于MDSCs具有强大的免疫抑制能力，它们在几种自身免疫性疾病中具有治疗作用。另外，研究发现MDSCs在其他心血管疾病（如动脉粥样硬化、急性冠状动脉综合征和高血压）的形成和发展中起重要作用。在这篇综述中，我们将讨论MDSCs在心血管疾病发病机制和治疗中的作用。
