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C反应蛋白在急性心肌梗死中的作用:揭示诊断、预后及治疗方面的见解

The Role of C-Reactive Protein in Acute Myocardial Infarction: Unmasking Diagnostic, Prognostic, and Therapeutic Insights.

作者信息

Mitsis Andreas, Sokratous Stefanos, Karmioti Georgia, Kyriakou Michaela, Drakomathioulakis Michail, Myrianthefs Michael M, Eftychiou Christos, Kadoglou Nikolaos P E, Tzikas Stergios, Fragakis Nikolaos, Kassimis George

机构信息

Cardiology Department, State Health Services Organization, Nicosia General Hospital, 215 Old Road Nicosia-Limassol, Nicosia 2029, Cyprus.

Medical School, University of Cyprus, Nicosia 2115, Cyprus.

出版信息

J Clin Med. 2025 Jul 7;14(13):4795. doi: 10.3390/jcm14134795.

Abstract

C-reactive protein (CRP) has emerged as a valuable biomarker in acute myocardial infarction (AMI), offering multiple insights into diagnosis, prognosis, and therapeutic strategies. In the diagnostic domain, elevated CRP levels serve as an early indicator of AMI, aiding in prompt identification and initiation of treatment. Prognostically, CRP is a strong predictor of adverse outcomes post-AMI, correlating with increased mortality and cardiovascular events. Beyond its diagnostic and prognostic roles, CRP also exposes therapeutic avenues in AMI management. Targeting CRP through pharmacological interventions has shown promise in reducing inflammatory responses, thereby mitigating myocardial damage and improving clinical outcomes. However, CRP's low specificity, influenced by elevation in non-cardiac conditions, remains a clinical limitation that warrants consideration. This review comprehensively examines the evolving role of CRP in AMI, exploring its diagnostic accuracy, prognostic significance, and potential as a therapeutic target. The understanding of the complex role of CRP in AMI provides clinicians with valuable tools for risk stratification, treatment optimization, and personalized patient care in the acute setting.

摘要

C反应蛋白(CRP)已成为急性心肌梗死(AMI)中有价值的生物标志物,为诊断、预后和治疗策略提供了多方面的见解。在诊断领域,CRP水平升高是AMI的早期指标,有助于及时识别和开始治疗。在预后方面,CRP是AMI后不良结局的有力预测指标,与死亡率增加和心血管事件相关。除了其诊断和预后作用外,CRP还为AMI管理中的治疗途径提供了线索。通过药物干预靶向CRP在减少炎症反应方面已显示出前景,从而减轻心肌损伤并改善临床结局。然而,受非心脏疾病中CRP升高影响,其低特异性仍然是一个值得考虑的临床局限性。本综述全面探讨了CRP在AMI中不断演变的作用,研究其诊断准确性、预后意义以及作为治疗靶点的潜力。对CRP在AMI中复杂作用的理解为临床医生在急性情况下进行风险分层、优化治疗和提供个性化患者护理提供了有价值的工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bc3/12250735/0f69e20b7873/jcm-14-04795-g001.jpg

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