Department of Medicine, Weill Cornell Medicine, New York, New York.
Texas Heart Institute, Houston, Texas.
Am J Cardiol. 2023 Apr 15;193:70-74. doi: 10.1016/j.amjcard.2023.01.050. Epub 2023 Mar 4.
β-blockers are commonly used in heart failure with preserved ejection fraction (HFpEF), even in the absence of a compelling indication and despite the potential to cause harm. Identifying reasons for β-blocker prescription in HFpEF could permit the development of strategies to reduce unnecessary use and potentially improve medication prescribing patterns in this vulnerable population. We administered an online survey regarding β-blocker prescribing behavior to physicians trained in internal medicine or geriatrics (noncardiology physicians) and to cardiologists at 2 large academic medical centers. The survey assessed the reasons for β-blocker initiation, agreement regarding initiation and/or continuation of β-blockers by another clinician, and deprescribing behavior. The response rate was 28.2% (n = 231). Among respondents, 68.2% reported initiating β-blockers in patients with HFpEF. The most common reason for initiating a β-blocker was for treatment of an atrial arrhythmia. Notably, 23.7% of physicians reported initiating a β-blocker without an evidence-based indication. When a β-blocker was considered not necessary, 40.1% of physicians reported they were rarely or never willing to deprescribe. The most common reason for not deprescribing a β-blocker when the physician felt that a β-blocker was unnecessary was the concern about interfering with another physicians' treatment plan (76.6%). In conclusion, a significant proportion of noncardiology physicians and cardiologists report prescribing β-blockers to patients with HFpEF, even when evidence-based indications are absent, and rarely deprescribe β-blockers in these scenarios.
β受体阻滞剂常用于射血分数保留的心力衰竭(HFpEF)患者,即使没有明确的适应证,且可能存在潜在危害。明确 HFpEF 患者使用β受体阻滞剂的原因,有助于制定减少不必要使用的策略,并可能改善该脆弱人群的药物处方模式。我们向 2 家大型学术医疗中心接受过内科或老年病学(非心脏病学)培训的内科医生和心脏病专家进行了一项关于β受体阻滞剂处方行为的在线调查。该调查评估了β受体阻滞剂起始的原因、另一位临床医生对起始和/或继续使用β受体阻滞剂的意见,以及停药行为。应答率为 28.2%(n=231)。在应答者中,68.2%的人报告在 HFpEF 患者中起始了β受体阻滞剂。起始β受体阻滞剂最常见的原因是治疗房性心律失常。值得注意的是,23.7%的医生报告在没有基于证据的适应证的情况下起始了β受体阻滞剂。当认为β受体阻滞剂不必要时,40.1%的医生报告他们很少或从不愿意停药。当医生认为β受体阻滞剂不必要但仍未停药时,最常见的原因是担心干扰其他医生的治疗计划(76.6%)。总之,相当一部分非心脏病学医生和心脏病专家报告在 HFpEF 患者中使用β受体阻滞剂,即使缺乏基于证据的适应证,并且在这些情况下很少停药。