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本文引用的文献

1
Effect of β-Blocker Withdrawal on Functional Capacity in Heart Failure and Preserved Ejection Fraction.β受体阻滞剂撤药对射血分数保留的心力衰竭患者功能能力的影响。
J Am Coll Cardiol. 2021 Nov 23;78(21):2042-2056. doi: 10.1016/j.jacc.2021.08.073.
2
Empagliflozin in Heart Failure with a Preserved Ejection Fraction.恩格列净治疗射血分数保留的心力衰竭。
N Engl J Med. 2021 Oct 14;385(16):1451-1461. doi: 10.1056/NEJMoa2107038. Epub 2021 Aug 27.
3
Attitudes toward deprescribing among adults with heart failure with preserved ejection fraction.射血分数保留的心力衰竭成人对药物减量的态度。
J Am Geriatr Soc. 2021 Jul;69(7):1948-1955. doi: 10.1111/jgs.17204. Epub 2021 May 12.
4
Specialty-Based Variability in Diagnosing and Managing Heart Failure With Preserved Ejection Fraction.基于专业的射血分数保留型心力衰竭诊断和管理的变异性。
Mayo Clin Proc. 2020 Apr;95(4):669-675. doi: 10.1016/j.mayocp.2019.09.026.
5
Association of β-Blocker Use With Heart Failure Hospitalizations and Cardiovascular Disease Mortality Among Patients With Heart Failure With a Preserved Ejection Fraction: A Secondary Analysis of the TOPCAT Trial.β受体阻滞剂的使用与射血分数保留的心力衰竭患者心力衰竭住院和心血管疾病死亡率的关系:TOPCAT 试验的二次分析。
JAMA Netw Open. 2019 Dec 2;2(12):e1916598. doi: 10.1001/jamanetworkopen.2019.16598.
6
Heart Rate and Heart Failure With Preserved Ejection Fraction: Time to Slow β-Blocker Use?心率与射血分数保留的心力衰竭:是时候减少β受体阻滞剂的使用了吗?
Circ Heart Fail. 2019 Aug;12(8):e006213. doi: 10.1161/CIRCHEARTFAILURE.119.006213. Epub 2019 Aug 1.
7
Physician Perspectives on Deprescribing Cardiovascular Medications for Older Adults.医师视角下老年人群心血管药物的逐渐减停。
J Am Geriatr Soc. 2020 Jan;68(1):78-86. doi: 10.1111/jgs.16157. Epub 2019 Sep 11.
8
Angiotensin-Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction.血管紧张素-脑啡肽酶抑制剂在射血分数保留的心力衰竭中的应用。
N Engl J Med. 2019 Oct 24;381(17):1609-1620. doi: 10.1056/NEJMoa1908655. Epub 2019 Sep 1.
9
The Evolution of β-Blockers in Coronary Artery Disease and Heart Failure (Part 1/5).β受体阻滞剂在冠状动脉疾病和心力衰竭中的演变(第一部分/ 5)。
J Am Coll Cardiol. 2019 Aug 6;74(5):672-682. doi: 10.1016/j.jacc.2019.04.067.
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Deprescribing in Older Adults With Cardiovascular Disease.老年心血管病患者的药物减量。
J Am Coll Cardiol. 2019 May 28;73(20):2584-2595. doi: 10.1016/j.jacc.2019.03.467.

医生对射血分数保留的心力衰竭中使用β受体阻滞剂的看法。

Physician Perspectives on the Use of Beta Blockers in Heart Failure With Preserved Ejection Fraction.

机构信息

Department of Medicine, Weill Cornell Medicine, New York, New York.

Texas Heart Institute, Houston, Texas.

出版信息

Am J Cardiol. 2023 Apr 15;193:70-74. doi: 10.1016/j.amjcard.2023.01.050. Epub 2023 Mar 4.

DOI:10.1016/j.amjcard.2023.01.050
PMID:36878055
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10114214/
Abstract

β-blockers are commonly used in heart failure with preserved ejection fraction (HFpEF), even in the absence of a compelling indication and despite the potential to cause harm. Identifying reasons for β-blocker prescription in HFpEF could permit the development of strategies to reduce unnecessary use and potentially improve medication prescribing patterns in this vulnerable population. We administered an online survey regarding β-blocker prescribing behavior to physicians trained in internal medicine or geriatrics (noncardiology physicians) and to cardiologists at 2 large academic medical centers. The survey assessed the reasons for β-blocker initiation, agreement regarding initiation and/or continuation of β-blockers by another clinician, and deprescribing behavior. The response rate was 28.2% (n = 231). Among respondents, 68.2% reported initiating β-blockers in patients with HFpEF. The most common reason for initiating a β-blocker was for treatment of an atrial arrhythmia. Notably, 23.7% of physicians reported initiating a β-blocker without an evidence-based indication. When a β-blocker was considered not necessary, 40.1% of physicians reported they were rarely or never willing to deprescribe. The most common reason for not deprescribing a β-blocker when the physician felt that a β-blocker was unnecessary was the concern about interfering with another physicians' treatment plan (76.6%). In conclusion, a significant proportion of noncardiology physicians and cardiologists report prescribing β-blockers to patients with HFpEF, even when evidence-based indications are absent, and rarely deprescribe β-blockers in these scenarios.

摘要

β受体阻滞剂常用于射血分数保留的心力衰竭(HFpEF)患者,即使没有明确的适应证,且可能存在潜在危害。明确 HFpEF 患者使用β受体阻滞剂的原因,有助于制定减少不必要使用的策略,并可能改善该脆弱人群的药物处方模式。我们向 2 家大型学术医疗中心接受过内科或老年病学(非心脏病学)培训的内科医生和心脏病专家进行了一项关于β受体阻滞剂处方行为的在线调查。该调查评估了β受体阻滞剂起始的原因、另一位临床医生对起始和/或继续使用β受体阻滞剂的意见,以及停药行为。应答率为 28.2%(n=231)。在应答者中,68.2%的人报告在 HFpEF 患者中起始了β受体阻滞剂。起始β受体阻滞剂最常见的原因是治疗房性心律失常。值得注意的是,23.7%的医生报告在没有基于证据的适应证的情况下起始了β受体阻滞剂。当认为β受体阻滞剂不必要时,40.1%的医生报告他们很少或从不愿意停药。当医生认为β受体阻滞剂不必要但仍未停药时,最常见的原因是担心干扰其他医生的治疗计划(76.6%)。总之,相当一部分非心脏病学医生和心脏病专家报告在 HFpEF 患者中使用β受体阻滞剂,即使缺乏基于证据的适应证,并且在这些情况下很少停药。